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2014 ; 18
(5
): 291-6
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Comparison of post-operative ICU sedation between dexmedetomidine and propofol in
Indian population
#MMPMID24914257
Shah PN
; Dongre V
; Patil V
; Pandya S
; Mungantiwar A
; Choulwar A
Indian J Crit Care Med
2014[May]; 18
(5
): 291-6
PMID24914257
show ga
CONTEXT: Critically ill patients requiring mechanical ventilation frequently need
sedatives and analgesics to facilitate their care. Dexmedetomidine, a
short-acting alpha-2-agonist, possesses anxiolytic, anesthetic, hypnotic, and
analgesic properties. AIMS: The objective of this study was to evaluate the
efficacy and safety of dexmedetomidine in comparison to propofol in the
management of sedation for post-operative intensive care unit (ICU) patients, as
a sedative agent. SETTINGS AND DESIGN: Teaching hospital, A phase III,
prospective, open, randomized and comparative. MATERIALS AND METHODS: Thirty
patients who were ambulatory and who required the post-operative mechanical
ventilation or post-operative sedation were enrolled, in which 15 patients
received Dexmedetomidine and remaining 15 patients received propofol. All these
patients were treated for the period of 8 to 24 h. STATISTICAL ANALYSIS USED:
Data were analyzed using Student's t-test and Chi-square test. The value of P <
0.05 was considered as statistically significant. RESULTS: Demographic data were
comparable. Pulse rate, respiratory rate and blood pressure were comparable.
Depth of sedation and extubation time were similar. To maintain analgesia
throughout the study period, patients receiving propofol infusions required
significantly more analgesics than patients receiving Dexmedetomidine.
CONCLUSIONS: Dexmedetomidine appears to be a safe and acceptable ICU sedative
agent when both the clinician's and patient's perspectives are considered.