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10.1074/jbc.M113.539601

http://scihub22266oqcxt.onion/10.1074/jbc.M113.539601
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C4047405!4047405!24770415
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suck abstract from ncbi


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pmid24770415      J+Biol+Chem 2014 ; 289 (23): 16374-88
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  • Myeloid Cell-specific Disruption of Period1 and Period2 Exacerbates Diet-induced Inflammation and Insulin Resistance* #MMPMID24770415
  • Xu H; Li H; Woo SL; Kim SM; Shende VR; Neuendorff N; Guo X; Guo T; Qi T; Pei Y; Zhao Y; Hu X; Zhao J; Chen L; Chen L; Ji JY; Alaniz RC; Earnest DJ; Wu C
  • J Biol Chem 2014[Jun]; 289 (23): 16374-88 PMID24770415show ga
  • Background: Circadian clockworks gate macrophage inflammatory responses.Results: Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced adipose and liver inflammation and systemic insulin resistance.Conclusion: Macrophage circadian dysregulation contributes to diet-induced inflammation and metabolic phenotypes in adipose and liver tissues.Significance: Interactions between circadian clocks and pathways mediating adipose tissue inflammation are critical in the development and possibly treatment of obesity-associated metabolic disorders.
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