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10.1074/jbc.M113.539601 http://scihub22266oqcxt.onion/10.1074/jbc.M113.539601 C4047405!4047405 !24770415     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 267.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24770415 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       J+Biol+Chem 2014 ; 289 (23 ): 16374-88 Nephropedia Template TP {{tp|p=24770415 |t=2014. Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance |pdf=|usr=}}{{24770415 }} gab.com Text Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24770415 #FOAvip The circadian clockworks gate macrophage inflammatory responses. Given the association between clock dysregulation and metabolic disorders, we conducted experiments to determine the extent to which over-nutrition modulates macrophage clock function and whether macrophage circadian dysregulation is a key factor linking over-nutrition to macrophage proinflammatory activation, adipose tissue inflammation, and systemic insulin resistance. Our results demonstrate that 1) macrophages from high fat diet-fed mice are marked by dysregulation of the molecular clockworks in conjunction with increased proinflammatory activation, 2) global disruption of the clock genes Period1 (Per1) and Per2 recapitulates this amplified macrophage proinflammatory activation, 3) adoptive transfer of Per1/2-disrupted bone marrow cells into wild-type mice potentiates high fat diet-induced adipose and liver tissue inflammation and systemic insulin resistance, and 4) Per1/2-disrupted macrophages similarly exacerbate inflammatory responses and decrease insulin sensitivity in co-cultured adipocytes in vitro. Furthermore, PPAR? levels are decreased in Per1/2-disrupted macrophages and PPAR?2 overexpression ameliorates Per1/2 disruption-associated macrophage proinflammatory activation, suggesting that this transcription factor may link the molecular clockworks to signaling pathways regulating macrophage polarization. Thus, macrophage circadian clock dysregulation is a key process in the physiological cascade by which diet-induced obesity triggers macrophage proinflammatory activation, adipose tissue inflammation, and insulin resistance. Twit Text FOAVip Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24770415 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24770415 #FOAvip English Wikipedia <ref>{{Cite pmid|24770415 }}</ref> Myeloid cell-specific disruption of Period1 and Period2 exacerbates diet-induced inflammation and insulin resistance #MMPMID24770415 Xu H ; Li H ; Woo SL ; Kim SM ; Shende VR ; Neuendorff N ; Guo X ; Guo T ; Qi T ; Pei Y ; Zhao Y ; Hu X ; Zhao J ; Chen L ; Chen L ; Ji JY ; Alaniz RC ; Earnest DJ ; Wu C J Biol Chem 2014[Jun]; 289 (23 ): 16374-88 PMID24770415 show ga The circadian clockworks gate macrophage inflammatory responses. Given the association between clock dysregulation and metabolic disorders, we conducted experiments to determine the extent to which over-nutrition modulates macrophage clock function and whether macrophage circadian dysregulation is a key factor linking over-nutrition to macrophage proinflammatory activation, adipose tissue inflammation, and systemic insulin resistance. Our results demonstrate that 1) macrophages from high fat diet-fed mice are marked by dysregulation of the molecular clockworks in conjunction with increased proinflammatory activation, 2) global disruption of the clock genes Period1 (Per1) and Per2 recapitulates this amplified macrophage proinflammatory activation, 3) adoptive transfer of Per1/2-disrupted bone marrow cells into wild-type mice potentiates high fat diet-induced adipose and liver tissue inflammation and systemic insulin resistance, and 4) Per1/2-disrupted macrophages similarly exacerbate inflammatory responses and decrease insulin sensitivity in co-cultured adipocytes in vitro. Furthermore, PPAR? levels are decreased in Per1/2-disrupted macrophages and PPAR?2 overexpression ameliorates Per1/2 disruption-associated macrophage proinflammatory activation, suggesting that this transcription factor may link the molecular clockworks to signaling pathways regulating macrophage polarization. Thus, macrophage circadian clock dysregulation is a key process in the physiological cascade by which diet-induced obesity triggers macrophage proinflammatory activation, adipose tissue inflammation, and insulin resistance. |*Diet, High-Fat [MESH] |*Insulin Resistance [MESH] |Adipocytes/metabolism [MESH] |Animals [MESH] |Bone Marrow Cells/*metabolism [MESH] |Coculture Techniques [MESH] |Inflammation/*metabolism [MESH] |Macrophages/metabolism [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |PPAR gamma/metabolism [MESH]Myeloid cell-specific disruption of Period1 and Period2 exacerbates di(epmc).pdf DeepDyve Pubget Overpricing