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10.1074/jbc.M114.556803

http://scihub22266oqcxt.onion/10.1074/jbc.M114.556803
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C4047401!4047401!24778182
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suck abstract from ncbi


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pmid24778182      J+Biol+Chem 2014 ; 289 (23): 16326-35
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  • ?-SNAP Interferes with the Zippering of the SNARE Protein Membrane Fusion Machinery #MMPMID24778182
  • Park Y; Vennekate W; Yavuz H; Preobraschenski J; Hernandez JM; Riedel D; Walla PJ; Jahn R
  • J Biol Chem 2014[Jun]; 289 (23): 16326-35 PMID24778182show ga
  • Background: Soluble N-ethylmaleimide-sensitive factor attachment protein ? (?-SNAP) regulates the pre-fusion step as well as SNARE disassembly.Results: ?-SNAP on its own interferes with SNARE zippering and inhibits chromaffin granule fusion, but not synaptic vesicle fusion.Conclusion: Retardation of SNARE zippering by ?-SNAP results in the partial SNARE zippering.Significance: This is the first direct evidence showing the partial SNARE zippering in the physiological context.
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