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10.1074/jbc.M114.562355 http://scihub22266oqcxt.onion/10.1074/jbc.M114.562355 C4047398!4047398!24770419     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Biol+Chem 2014 ; 289 (23): 16290-302 Nephropedia Template TP {{tp|p=24770419|t=2014. Inefficient Translocation of Preproinsulin Contributes to Pancreatic ? Cell Failure and Late-onset Diabetes* |pdf=|usr=}}{{24770419}} gab.com Text Inefficient Translocation of Preproinsulin Contributes to Pancreatic Cell Failure and Late-onset Diabetes* JO: J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24770419 #FOAvip Background: Preproinsulin signal peptide mutations have been linked to human diabetes.Results: Preproinsulin mutants fail to be fully translocated across the endoplasmic reticulum membrane, accumulate in the cytosol, and lead to ? cell death.Conclusion: Cytosolic preproinsulin accumulation contributes to ? cell failure.Significance: This reveals a novel pathogenesis of diabetes associated with inefficient preproinsulin translocation and cytosolic accumulation. Twit Text FOAVip Inefficient Translocation of Preproinsulin Contributes to Pancreatic Cell Failure and Late-onset Diabetes* ????J Biol Chem http://www.kidney.de/pget.php?&tw=1&pmid=24770419 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24770419 #FOAvip English Wikipedia <ref>{{Cite pmid|24770419}}</ref> Inefficient Translocation of Preproinsulin Contributes to Pancreatic ? Cell Failure and Late-onset Diabetes* #MMPMID24770419 Guo H; Xiong Y; Witkowski P; Cui J; Wang Lj; Sun J; Lara-Lemus R; Haataja L; Hutchison K; Shan So; Arvan P; Liu M J Biol Chem 2014[Jun]; 289 (23): 16290-302 PMID24770419show ga Background: Preproinsulin signal peptide mutations have been linked to human diabetes.Results: Preproinsulin mutants fail to be fully translocated across the endoplasmic reticulum membrane, accumulate in the cytosol, and lead to ? cell death.Conclusion: Cytosolic preproinsulin accumulation contributes to ? cell failure.Significance: This reveals a novel pathogenesis of diabetes associated with inefficient preproinsulin translocation and cytosolic accumulation. äInefficient Translocation of Preproinsulin Contributes to Pancreatic ?(epmc).pdf DeepDyve Pubget Overpricing