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10.1074/jbc.M113.527424

http://scihub22266oqcxt.onion/10.1074/jbc.M113.527424
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C4047392!4047392!24782312
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suck abstract from ncbi


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pmid24782312      J+Biol+Chem 2014 ; 289 (23): 16223-38
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  • Poly(ADP-ribose) Polymerase 1 (PARP1) Associates with E3 Ubiquitin-Protein Ligase UHRF1 and Modulates UHRF1 Biological Functions* #MMPMID24782312
  • De Vos M; El Ramy R; Quénet D; Wolf P; Spada F; Magroun N; Babbio F; Schreiber V; Leonhardt H; Bonapace IM; Dantzer F
  • J Biol Chem 2014[Jun]; 289 (23): 16223-38 PMID24782312show ga
  • Background: PARP1 and UHRF1 participate in heterochromatin dynamics and the maintenance of DNA methylation, raising the question of whether both proteins cooperate in these events.Results: We reveal a physical and functional poly(ADP-ribose)-mediated interaction of PARP1 with UHRF1 that helps to adjust UHRF1-regulated biological activities.Conclusion: PARP1 is a regulator of UHRF1-controlled H4K20me3 accumulation and DNMT1 expression.Significance: PARP1 associates and cooperates with UHRF1 to regulate heterochromatin-associated events.
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