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10.1074/jbc.M114.556530

http://scihub22266oqcxt.onion/10.1074/jbc.M114.556530
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C4047384!4047384!24737315
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suck abstract from ncbi

pmid24737315      J+Biol+Chem 2014 ; 289 (23): 16114-28
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  • Endorepellin Evokes Autophagy in Endothelial Cells* #MMPMID24737315
  • Poluzzi C; Casulli J; Goyal A; Mercer TJ; Neill T; Iozzo RV
  • J Biol Chem 2014[Jun]; 289 (23): 16114-28 PMID24737315show ga
  • Background: Endorepellin inhibits angiogenesis by simultaneously binding the ?2?1 integrin and VEGFR2, attenuating the PI3K/Akt/mTOR and PKC/JNK/AP1 signaling pathways.Results: Endorepellin evokes autophagy by inducing Beclin 1 and LC3 downstream of VEGFR2 in a Peg3-dependent manner.Conclusion: Endorepellin causes endothelial cell autophagy through VEGFR2 independent of the ?2?1 integrin.Significance: Endorepellin-evoked endothelial cell autophagy represents a promising strategy for angiostatic-based therapeutics.
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