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10.1074/jbc.M114.552216

http://scihub22266oqcxt.onion/10.1074/jbc.M114.552216
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C4047377!4047377!24764292
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suck abstract from ncbi


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pmid24764292      J+Biol+Chem 2014 ; 289 (23): 16016-31
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  • The RUNX2 Cistrome in Osteoblasts: CHARACTERIZATION, DOWN-REGULATION FOLLOWING DIFFERENTIATION, AND RELATIONSHIP TO GENE EXPRESSION* #MMPMID24764292
  • Meyer MB; Benkusky NA; Pike JW
  • J Biol Chem 2014[Jun]; 289 (23): 16016-31 PMID24764292show ga
  • Background: RUNX2 is indispensable for mature osteoblast differentiation and function.Results: During osteogenic differentiation, RUNX2 along with C/EBP? bind throughout the genome near genes that are essential for the phenotype.Conclusion: Differentiation leads to a restricted RUNX2 cistrome that correlates with changes in gene expression.Significance: Broad genomic localization of RUNX2 during osteoblastogenesis highlights its role as a dynamic lineage-determining factor.
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