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10.1007/s10875-014-0038-z http://scihub22266oqcxt.onion/10.1007/s10875-014-0038-z C4047151!4047151!24760111     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Clin+Immunol 2014 ; 34 (5): 594-9 Nephropedia Template TP {{tp|p=24760111|t=2014. Elevated Double Negative T Cells in Pediatric Autoimmunity |pdf=|usr=}}{{24760111}} gab.com Text Elevated Double Negative T Cells in Pediatric Autoimmunity JO: J Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24760111 #FOAvip Purpose: Autoimmune diseases are thought to be caused by a loss of self-tolerance of the immune system. One candidate marker of immune dysregulation in autoimmune disease is the presence of increased double negative T cells (DNTs) in the periphery. DNTs are characteristically elevated in autoimmune lymphoproliferative syndrome, a systemic autoimmune disease caused by defective lymphocyte apoptosis due to Fas pathway defects. DNTs have also been found in the peripheral blood of adult patients with systemic lupus erythematosus (SLE), where they may be pathogenic. DNTs in children with autoimmune disease have not been investigated. Methods: We evaluated DNTs in pediatric patients with SLE, mixed connective tissue disease (MCTD), juvenile idiopathic arthritis (JIA), or elevated antinuclear antibody (ANA) but no systemic disease. DNTs (CD3+CD56?TCR??+CD4?CD8?) from peripheral blood mononuclear cells were analyzed by flow cytometry from 54 pediatric patients including: 23 SLE, 15 JIA, 11 ANA and 5 MCTD compared to 28 healthy controls. Results: Sixteen cases (29.6%) had elevated DNTs (? 2.5% of CD3+CD56?TCR??+ cells) compared to 1 (3.6%) control. Medication usage including cytotoxic drugs and absolute lymphocyte count were not associated with DNT levels, and percentages of DNTs were stable over time. Analysis of multiple phenotypic and activation markers showed increased CD45RA expression on DNTs from patients with autoimmune disease compared to controls. Conclusion: DNTs are elevated in a subset of pediatric patients with autoimmune disease and additional investigations are required to determine their precise role in autoimmunity. Twit Text FOAVip Elevated Double Negative T Cells in Pediatric Autoimmunity ????J Clin Immunol http://www.kidney.de/pget.php?&tw=1&pmid=24760111 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24760111 #FOAvip English Wikipedia <ref>{{Cite pmid|24760111}}</ref> Elevated Double Negative T Cells in Pediatric Autoimmunity #MMPMID24760111 Tarbox JA; Keppel MP; Topcagic N; Mackin C; Abdallah MB; Baszis KW; White AJ; French AR; Cooper MA J Clin Immunol 2014[Jul]; 34 (5): 594-9 PMID24760111show ga Purpose: Autoimmune diseases are thought to be caused by a loss of self-tolerance of the immune system. One candidate marker of immune dysregulation in autoimmune disease is the presence of increased double negative T cells (DNTs) in the periphery. DNTs are characteristically elevated in autoimmune lymphoproliferative syndrome, a systemic autoimmune disease caused by defective lymphocyte apoptosis due to Fas pathway defects. DNTs have also been found in the peripheral blood of adult patients with systemic lupus erythematosus (SLE), where they may be pathogenic. DNTs in children with autoimmune disease have not been investigated. Methods: We evaluated DNTs in pediatric patients with SLE, mixed connective tissue disease (MCTD), juvenile idiopathic arthritis (JIA), or elevated antinuclear antibody (ANA) but no systemic disease. DNTs (CD3+CD56?TCR??+CD4?CD8?) from peripheral blood mononuclear cells were analyzed by flow cytometry from 54 pediatric patients including: 23 SLE, 15 JIA, 11 ANA and 5 MCTD compared to 28 healthy controls. Results: Sixteen cases (29.6%) had elevated DNTs (? 2.5% of CD3+CD56?TCR??+ cells) compared to 1 (3.6%) control. Medication usage including cytotoxic drugs and absolute lymphocyte count were not associated with DNT levels, and percentages of DNTs were stable over time. Analysis of multiple phenotypic and activation markers showed increased CD45RA expression on DNTs from patients with autoimmune disease compared to controls. Conclusion: DNTs are elevated in a subset of pediatric patients with autoimmune disease and additional investigations are required to determine their precise role in autoimmunity. äElevated Double Negative T Cells in Pediatric Autoimmunity (epmc).pdf DeepDyve Pubget Overpricing