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10.1039/c3ib40170g http://scihub22266oqcxt.onion/10.1039/c3ib40170g C4046910!4046910!24763498     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Integr+Biol+(Camb) 2014 ; 6 (6): 603-10 Nephropedia Template TP {{tp|p=24763498|t=2014. A three-dimensional in vitro model of tumor cell intravasation |pdf=|usr=}}{{24763498}} gab.com Text A three-dimensional in vitro model of tumor cell intravasation JO: Integr Biol (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=24763498 #FOAvip Metastasis is the cause of over 90% of all human cancer deaths. Early steps in the metastatic process include: the formation of new blood vessels, the initiation of epithelial-mesenchymal transition (EMT), and the mobilization of tumor cells into the circulation. There are ongoing efforts to replicate the physiological landscape of human tumor tissue using three-dimensional in vitro culture models; however, few systems are able to capture the full range of authentic, complex in vivo events such as neovascularization and intravasation. Here we introduce the Prevascularized Tumor (PVT) model to investigate early events of solid tumor progression. PVT spheroids are composed of endothelial and tumor cells, and are embedded in a fibrin matrix containing fibroblasts. The PVT model facilitates two mechanisms of vessel formation: robust sprouting angiogenesis into the matrix, and contiguous vascularization within the spheroid. Furthermore, the PVT model enables the intravasation of tumor cells that is enhanced under low oxygen conditions and is also dependent on the key EMT transcription factor Slug. The PVT model provides a significant advance in the mimicry of human tumors in vitro and may improve investigation and targeting of events in the metastatic process. Twit Text FOAVip A three-dimensional in vitro model of tumor cell intravasation ????Integr Biol (Camb) http://www.kidney.de/pget.php?&tw=1&pmid=24763498 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24763498 #FOAvip English Wikipedia <ref>{{Cite pmid|24763498}}</ref> A three-dimensional in vitro model of tumor cell intravasation #MMPMID24763498 Ehsan SM; Welch-Reardon KM; Waterman ML; Hughes CC; George SC Integr Biol (Camb) 2014[Jun]; 6 (6): 603-10 PMID24763498show ga Metastasis is the cause of over 90% of all human cancer deaths. Early steps in the metastatic process include: the formation of new blood vessels, the initiation of epithelial-mesenchymal transition (EMT), and the mobilization of tumor cells into the circulation. There are ongoing efforts to replicate the physiological landscape of human tumor tissue using three-dimensional in vitro culture models; however, few systems are able to capture the full range of authentic, complex in vivo events such as neovascularization and intravasation. Here we introduce the Prevascularized Tumor (PVT) model to investigate early events of solid tumor progression. PVT spheroids are composed of endothelial and tumor cells, and are embedded in a fibrin matrix containing fibroblasts. The PVT model facilitates two mechanisms of vessel formation: robust sprouting angiogenesis into the matrix, and contiguous vascularization within the spheroid. Furthermore, the PVT model enables the intravasation of tumor cells that is enhanced under low oxygen conditions and is also dependent on the key EMT transcription factor Slug. The PVT model provides a significant advance in the mimicry of human tumors in vitro and may improve investigation and targeting of events in the metastatic process. äA three-dimensional in vitro model of tumor cell intravasation (epmc).pdf DeepDyve Pubget Overpricing