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10.1186/2051-5960-1-8 http://scihub22266oqcxt.onion/10.1186/2051-5960-1-8 C4046834!4046834 !24252267     free     free     free Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 233.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24252267 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Acta+Neuropathol+Commun 2013 ; 1 (1 ): 8 Nephropedia Template TP {{tp|p=24252267 |t=2013. Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases |pdf=|usr=}}{{24252267 }} gab.com Text Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases JO: Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=24252267 #FOAvip BACKGROUND: Sporadic, inherited and acquired prion diseases show distinct histological patterns of abnormal prion protein (PrP) deposits. Many of the inherited prion diseases show striking histological patterns, which often associate with specific mutations. Most reports have focused on the pattern of PrP deposition in the cortical or cerebellar grey matter. RESULTS: We observed that the subcortical white matter in inherited prion diseases frequently contained filamentous depositions of abnormal PrP, and we have analysed by immunohistochemistry, immunofluorescence and electron microscopy 35 cases of inherited prion disease seen at the UK National Prion Clinic. We report here that filamentous PrP is abundantly deposited in myelinated fibres in inherited prion diseases, in particular in those with N-terminal mutations. CONCLUSIONS: It is possible that the presence of filamentous PrP is related to the pathogenesis of inherited forms, which is different from those sporadic and acquired forms. Twit Text FOAVip Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases ????Acta Neuropathol Commun http://www.kidney.de/pget.php?&tw=1&pmid=24252267 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24252267 #FOAvip English Wikipedia <ref>{{Cite pmid|24252267 }}</ref> Filamentous white matter prion protein deposition is a distinctive feature of multiple inherited prion diseases #MMPMID24252267 Reiniger L ; Mirabile I ; Lukic A ; Wadsworth JD ; Linehan JM ; Groves M ; Lowe J ; Druyeh R ; Rudge P ; Collinge J ; Mead S ; Brandner S Acta Neuropathol Commun 2013[May]; 1 (1 ): 8 PMID24252267 show ga BACKGROUND: Sporadic, inherited and acquired prion diseases show distinct histological patterns of abnormal prion protein (PrP) deposits. Many of the inherited prion diseases show striking histological patterns, which often associate with specific mutations. Most reports have focused on the pattern of PrP deposition in the cortical or cerebellar grey matter. RESULTS: We observed that the subcortical white matter in inherited prion diseases frequently contained filamentous depositions of abnormal PrP, and we have analysed by immunohistochemistry, immunofluorescence and electron microscopy 35 cases of inherited prion disease seen at the UK National Prion Clinic. We report here that filamentous PrP is abundantly deposited in myelinated fibres in inherited prion diseases, in particular in those with N-terminal mutations. CONCLUSIONS: It is possible that the presence of filamentous PrP is related to the pathogenesis of inherited forms, which is different from those sporadic and acquired forms. |Adult [MESH] |Aged [MESH] |Aged, 80 and over [MESH] |Blotting, Western [MESH] |Brain/metabolism/ultrastructure [MESH] |Creutzfeldt-Jakob Syndrome/metabolism/pathology [MESH] |Female [MESH] |Fluorescent Antibody Technique [MESH] |Humans [MESH] |Immunohistochemistry [MESH] |Male [MESH] |Microscopy, Electron, Transmission [MESH] |Middle Aged [MESH] |PrPSc Proteins/genetics/*metabolism [MESH] |Prion Diseases/genetics/*metabolism/*pathology [MESH] |Prion Proteins [MESH] |Prions/genetics/metabolism [MESH]Filamentous white matter prion protein deposition is a distinctive fea(epmc).pdf DeepDyve Pubget Overpricing