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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Acta+Neuropathol+Commun
2013 ; 1
(1
): 33
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Classification of FTLD-TDP cases into pathological subtypes using antibodies
against phosphorylated and non-phosphorylated TDP43
#MMPMID24252630
Tan RH
; Shepherd CE
; Kril JJ
; McCann H
; McGeachie A
; McGinley C
; Affleck A
; Halliday GM
Acta Neuropathol Commun
2013[Jul]; 1
(1
): 33
PMID24252630
show ga
BACKGROUND: Two commercially available TDP43 antibodies (phosphorylated or
pTDP43, non-phosphorylated or iTDP43) are currently in use for the
neuropathological classification of FTLD-TDP cases into pathological subtypes. To
date, no studies have performed direct comparisons between these TDP43 antibodies
to determine if they identify the same FTLD-TDP subtypes. The reliability of
subtype classification with the use of either of these antibodies has also not
been investigated. The present study compares the severity of pathological
lesions identified with pTDP43 and iTDP43 in a cohort of 14 FTLD-TDP cases, and
assesses the accuracy and inter-observer reliability found with either of these
antibodies. RESULTS: pTDP43 identified a greater severity of pathological
inclusions across FTLD-TDP cases in comparison to iTDP43 and a higher
inter-observer of subtype classification was found with this antibody.
CONCLUSION: This study demonstrates a higher consistency across independent
observers in the pathological subtyping of FTLD-TDP cases with the use of a
pTDP43 antibody in comparison to the iTDP43 antibody, and corroborates the use of
pTDP43 for pathological classification of FTLD-TDP cases.