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10.1089/thy.2013.0573 http://scihub22266oqcxt.onion/10.1089/thy.2013.0573 C4046200!4046200!24417340     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Thyroid 2014 ; 24 (6): 958-65 Nephropedia Template TP {{tp|p=24417340|t=2014. Hobnail Variant of Papillary Thyroid Carcinoma: An Institutional Case Series and Molecular Profile |pdf=|usr=}}{{24417340}} gab.com Text Hobnail Variant of Papillary Thyroid Carcinoma: An Institutional Case Series and Molecular Profile JO: Thyroid http://www.kidney.de/pget.php?&tw=1&pmid=24417340 #FOAvip Background: Papillary thyroid carcinoma (PTC) is increasing in incidence while mortality is unchanged. Identifying patients with higher risk of recurrence and death is essential. Case series identify the hobnail variant of PTC (HVPTC), which is characterized by micropapillary architecture, apocrine features, and loss of cellular polarity. Herein, we describe the clinical course, pathologic features, and mutational profile of patients at our institution with HVPTC.Methods: A query into the surgical pathologic database (2009?2012) was performed, and clinicopathologic data were collected on all patients carrying the diagnosis of HVPTC. BRAFV600E testing was performed on paraffin-embedded blocks using SNaPshot mutational analysis.Results: Twelve patients with HVPTC were identified, with an average age of 54.1±18.8 years. Seven patients (63.6%) were AJCC Stage III or IV at presentation. Tumors were large (3.7±2.0?cm), some were multifocal (33.3%), and frequently with extrathyroidal extension (58.3%), lymphovascular invasion (41.7%), and lymph node metastasis (75%). Forty percent of the patients had concomitant tall cell features (TCF), and two had small foci of undifferentiated (anaplastic) thyroid carcinoma (ATC). Eighty percent of tumors undergoing mutational analysis had the BRAFV600E mutation, and the remaining 20% harbored a RET/PTC1 gene rearrangement. No other known thyroid cancer mutations were identified on SNaPshot analysis. At median follow-up of 26 months, four patients had recurrent or persistent disease, one of whom died from the disease one year after surgery.Conclusions: The hobnail variant of PTC has an aggressive behavior, with a high incidence of infiltrative tumors and metastatic disease. Strikingly, all tumors in our series harbored a PTC-associated genetic abnormality, either a BRAFV600E mutation (80%) or a RET/PTC1 rearrangement (20%). This histologic variant warrants further study, and patients with this diagnosis should be observed closely for recurrence. Twit Text FOAVip Hobnail Variant of Papillary Thyroid Carcinoma: An Institutional Case Series and Molecular Profile ????Thyroid http://www.kidney.de/pget.php?&tw=1&pmid=24417340 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24417340 #FOAvip English Wikipedia <ref>{{Cite pmid|24417340}}</ref> Hobnail Variant of Papillary Thyroid Carcinoma: An Institutional Case Series and Molecular Profile #MMPMID24417340 Lubitz CC; Economopoulos KP; Pawlak AC; Lynch K; Dias-Santagata D; Faquin WC; Sadow PM Thyroid 2014[Jun]; 24 (6): 958-65 PMID24417340show ga Background: Papillary thyroid carcinoma (PTC) is increasing in incidence while mortality is unchanged. Identifying patients with higher risk of recurrence and death is essential. Case series identify the hobnail variant of PTC (HVPTC), which is characterized by micropapillary architecture, apocrine features, and loss of cellular polarity. Herein, we describe the clinical course, pathologic features, and mutational profile of patients at our institution with HVPTC.Methods: A query into the surgical pathologic database (2009?2012) was performed, and clinicopathologic data were collected on all patients carrying the diagnosis of HVPTC. BRAFV600E testing was performed on paraffin-embedded blocks using SNaPshot mutational analysis.Results: Twelve patients with HVPTC were identified, with an average age of 54.1±18.8 years. Seven patients (63.6%) were AJCC Stage III or IV at presentation. Tumors were large (3.7±2.0?cm), some were multifocal (33.3%), and frequently with extrathyroidal extension (58.3%), lymphovascular invasion (41.7%), and lymph node metastasis (75%). Forty percent of the patients had concomitant tall cell features (TCF), and two had small foci of undifferentiated (anaplastic) thyroid carcinoma (ATC). Eighty percent of tumors undergoing mutational analysis had the BRAFV600E mutation, and the remaining 20% harbored a RET/PTC1 gene rearrangement. No other known thyroid cancer mutations were identified on SNaPshot analysis. At median follow-up of 26 months, four patients had recurrent or persistent disease, one of whom died from the disease one year after surgery.Conclusions: The hobnail variant of PTC has an aggressive behavior, with a high incidence of infiltrative tumors and metastatic disease. Strikingly, all tumors in our series harbored a PTC-associated genetic abnormality, either a BRAFV600E mutation (80%) or a RET/PTC1 rearrangement (20%). This histologic variant warrants further study, and patients with this diagnosis should be observed closely for recurrence. äHobnail Variant of Papillary Thyroid Carcinoma: An Institutional Case (epmc).pdf DeepDyve Pubget Overpricing