GATA3: A master of many trades in immune regulation #MMPMID24786134
Wan YY
Trends Immunol 2014[Jun]; 35 (6): 233-42 PMID24786134show ga
GATA3 has conventionally been regarded as a transcription factor that drives the differentiation of T helper (Th) 2 cells. Increasing evidence points to function for GATA3 beyond controlling Th2 differentiation. GATA3 regulates T cell development, proliferation and maintenance. Furthermore, recent studies have demonstrated important roles for GATA3 in innate lymphoid cells. Thus GATA3 emerges as a factor with diverse functions in immune regulation, which are in some cases cell-type specific and in others shared by multiple cell types. Here I discuss recent discoveries and the current understanding of the functions of GATA3 in immune regulation.