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10.1016/j.semcdb.2014.03.017 http://scihub22266oqcxt.onion/10.1016/j.semcdb.2014.03.017 C4043890!4043890!24662891     free     free     free Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 219.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Semin+Cell+Dev+Biol 2014 ; ä (ä): 121-30 Nephropedia Template TP {{tp|p=24662891|t=2014. MCM10: one tool for all - integrity, maintenance and damage control |pdf=|usr=}}{{24662891}} gab.com Text MCM10: one tool for all - integrity, maintenance and damage control JO: Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=24662891 #FOAvip Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and ssDNA appears vital for this function. In addition, Mcm10 interacts with multiple players at the replication fork, including DNA polymerase-? and proliferating cell nuclear antigen with which it cooperates during DNA elongation. Mcm10 lacks enzymatic function, but instead provides the replication apparatus with an oligomeric scaffold that likely acts in the coordination of DNA unwinding and DNA synthesis. Not surprisingly, loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. Here, we review Mcm10's structure and function and explain how it contributes to the maintenance of genome integrity. Twit Text FOAVip MCM10: one tool for all - integrity, maintenance and damage control ????Semin Cell Dev Biol http://www.kidney.de/pget.php?&tw=1&pmid=24662891 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24662891 #FOAvip English Wikipedia <ref>{{Cite pmid|24662891}}</ref> MCM10: one tool for all - integrity, maintenance and damage control #MMPMID24662891 Thu YM; Bielinsky AK Semin Cell Dev Biol 2014[Jun]; ä (ä): 121-30 PMID24662891show ga Minichromsome maintenance protein 10 (Mcm10) is an essential replication factor that is required for the activation of the Cdc45:Mcm2-7:GINS helicase. Mcm10's ability to bind both ds and ssDNA appears vital for this function. In addition, Mcm10 interacts with multiple players at the replication fork, including DNA polymerase-? and proliferating cell nuclear antigen with which it cooperates during DNA elongation. Mcm10 lacks enzymatic function, but instead provides the replication apparatus with an oligomeric scaffold that likely acts in the coordination of DNA unwinding and DNA synthesis. Not surprisingly, loss of Mcm10 engages checkpoint, DNA repair and SUMO-dependent rescue pathways that collectively counteract replication stress and chromosome breakage. Here, we review Mcm10's structure and function and explain how it contributes to the maintenance of genome integrity. äMCM10: one tool for all - integrity, maintenance and damage control (epmc).pdf DeepDyve Pubget Overpricing