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2014 ; 114
(9
): 1516-31
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Mathematical approaches to understanding and imaging atrial fibrillation:
significance for mechanisms and management
#MMPMID24763468
Trayanova NA
Circ Res
2014[Apr]; 114
(9
): 1516-31
PMID24763468
show ga
Atrial fibrillation (AF) is the most common sustained arrhythmia in humans. The
mechanisms that govern AF initiation and persistence are highly complex, of
dynamic nature, and involve interactions across multiple temporal and spatial
scales in the atria. This article aims to review the mathematical modeling and
computer simulation approaches to understanding AF mechanisms and aiding in its
management. Various atrial modeling approaches are presented, with descriptions
of the methodological basis and advancements in both lower-dimensional and
realistic geometry models. A review of the most significant mechanistic insights
made by atrial simulations is provided. The article showcases the contributions
that atrial modeling and simulation have made not only to our understanding of
the pathophysiology of atrial arrhythmias, but also to the development of AF
management approaches. A summary of the future developments envisioned for the
field of atrial simulation and modeling is also presented. The review contends
that computational models of the atria assembled with data from clinical imaging
modalities that incorporate electrophysiological and structural remodeling could
become a first line of screening for new AF therapies and approaches, new
diagnostic developments, and new methods for arrhythmia prevention.