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10.12659/AJCR.890180 http://scihub22266oqcxt.onion/10.12659/AJCR.890180 C4043539!4043539!24900166     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Case+Rep 2014 ; 15 (ä): 235-8 Nephropedia Template TP {{tp|p=24900166|t=2014. Interferon-alpha-induced sarcoidosis in a patient being treated for hepatitis C |pdf=|usr=}}{{24900166}} gab.com Text Interferon-alpha-induced sarcoidosis in a patient being treated for hepatitis C JO: Am J Case Rep http://www.kidney.de/pget.php?&tw=1&pmid=24900166 #FOAvip Patient: Female, 43Final Diagnosis: ?Symptoms: Diarrhea ? generalized weakness ? headache ? lightheadedness ? nausea ? rash ? short of breath ? vomitingMedication: ?Clinical Procedure: ?Specialty: PulmonologyObjective:: Rare diseae Background:: IFN-alpha-2b in combination with ribavirin is now the standard of care for the treatment of hepatitis C. Sarcoidosis is a chronic multisystem granulomatous disorder characterized by noncaseating granulomas in the involved organs. The pathologic hallmark of sarcoidosis is the presence of noncaseating granulomas in the interstitium that typically involve the lymphatics. Case Report:: A 43-year-old woman presented to our care with 2-week history of nausea, vomiting, diarrhea, shortness of breath, migraine headache, maculopapular rash, generalized weakness, and lightheadedness. She had been treated for hepatitis C with telaprevir, ribavirin, and interferon-alpha-2b for 6 months. Chest radiograph showed bilateral diffuse prominence of bronchovascular markings. CT of the chest revealed bilateral diffuse centrilobular nodules with associated intralobular septal thickening, thickening of the central peribronchovascular interstitium, nodularity of the major fissures, and mediastinal lymphadenopathy. These findings were suspicious for atypical pulmonary sarcoidosis, possibly interferon-induced. The pathology of the mediastinal lymph node biopsy revealed noncaseating granulomatous inflammation consistent with the diagnosis of pulmonary sarcoidosis. Pathology of the skin punch biopsy showed giant-cell granulomatous inflammation without necrosis. The patient was started on prednisone 40 mg daily with a steroid tapering course for 8 weeks. Conclusions:: The management of IFN-induced sarcoidosis includes the discontinuation of IFN therapy with or without the administration of systemic corticosteroids. With the increasing prevalence of HCV in the United States, it is likely that more IFN-alpha-induced sarcoidosis will be encountered by clinicians. Twit Text FOAVip Interferon-alpha-induced sarcoidosis in a patient being treated for hepatitis C ????Am J Case Rep http://www.kidney.de/pget.php?&tw=1&pmid=24900166 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900166 #FOAvip English Wikipedia <ref>{{Cite pmid|24900166}}</ref> Interferon-alpha-induced sarcoidosis in a patient being treated for hepatitis C #MMPMID24900166 Trien R; Cooper CJ; Paez D; Colon E; Ajmal S; Salameh H Am J Case Rep 2014[]; 15 (ä): 235-8 PMID24900166show ga Patient: Female, 43Final Diagnosis: ?Symptoms: Diarrhea ? generalized weakness ? headache ? lightheadedness ? nausea ? rash ? short of breath ? vomitingMedication: ?Clinical Procedure: ?Specialty: PulmonologyObjective:: Rare diseae Background:: IFN-alpha-2b in combination with ribavirin is now the standard of care for the treatment of hepatitis C. Sarcoidosis is a chronic multisystem granulomatous disorder characterized by noncaseating granulomas in the involved organs. The pathologic hallmark of sarcoidosis is the presence of noncaseating granulomas in the interstitium that typically involve the lymphatics. Case Report:: A 43-year-old woman presented to our care with 2-week history of nausea, vomiting, diarrhea, shortness of breath, migraine headache, maculopapular rash, generalized weakness, and lightheadedness. She had been treated for hepatitis C with telaprevir, ribavirin, and interferon-alpha-2b for 6 months. Chest radiograph showed bilateral diffuse prominence of bronchovascular markings. CT of the chest revealed bilateral diffuse centrilobular nodules with associated intralobular septal thickening, thickening of the central peribronchovascular interstitium, nodularity of the major fissures, and mediastinal lymphadenopathy. These findings were suspicious for atypical pulmonary sarcoidosis, possibly interferon-induced. The pathology of the mediastinal lymph node biopsy revealed noncaseating granulomatous inflammation consistent with the diagnosis of pulmonary sarcoidosis. Pathology of the skin punch biopsy showed giant-cell granulomatous inflammation without necrosis. The patient was started on prednisone 40 mg daily with a steroid tapering course for 8 weeks. Conclusions:: The management of IFN-induced sarcoidosis includes the discontinuation of IFN therapy with or without the administration of systemic corticosteroids. With the increasing prevalence of HCV in the United States, it is likely that more IFN-alpha-induced sarcoidosis will be encountered by clinicians. äInterferon-alpha-induced sarcoidosis in a patient being treated for he(epmc).pdf DeepDyve Pubget Overpricing