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10.1242/jcs.142349 http://scihub22266oqcxt.onion/10.1242/jcs.142349 C4043320!4043320 !24659804     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24659804 &cmd=llinks): Failed to open stream: HTTP request failed! 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Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers |pdf=|usr=}}{{24659804 }} gab.com Text Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=24659804 #FOAvip Adherens junctions and desmosomes integrate the cytoskeletons of adjacent cells into a mechanical syncitium. In doing so, intercellular junctions endow tissues with the strength needed to withstand the mechanical stresses encountered in normal physiology and to coordinate tension during morphogenesis. Though much is known about the biological mechanisms underlying junction formation, little is known about how tissue-scale mechanical properties are established. Here, we use deep atomic force microscopy (AFM) indentation to measure the apparent stiffness of epithelial monolayers reforming from dissociated cells and examine which cellular processes give rise to tissue-scale mechanics. We show that the formation of intercellular junctions coincided with an increase in the apparent stiffness of reforming monolayers that reflected the generation of a tissue-level tension. Tension rapidly increased, reaching a maximum after 150?min, before settling to a lower level over the next 3?h as monolayers established homeostasis. The emergence of tissue tension correlated with the formation of adherens junctions but not desmosomes. As a consequence, inhibition of any of the molecular mechanisms participating in adherens junction initiation, remodelling and maturation significantly impeded the emergence of tissue-level tension in monolayers. Twit Text FOAVip Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=24659804 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24659804 #FOAvip English Wikipedia <ref>{{Cite pmid|24659804 }}</ref> Formation of adherens junctions leads to the emergence of a tissue-level tension in epithelial monolayers #MMPMID24659804 Harris AR ; Daeden A ; Charras GT J Cell Sci 2014[Jun]; 127 (Pt 11 ): 2507-17 PMID24659804 show ga Adherens junctions and desmosomes integrate the cytoskeletons of adjacent cells into a mechanical syncitium. In doing so, intercellular junctions endow tissues with the strength needed to withstand the mechanical stresses encountered in normal physiology and to coordinate tension during morphogenesis. Though much is known about the biological mechanisms underlying junction formation, little is known about how tissue-scale mechanical properties are established. Here, we use deep atomic force microscopy (AFM) indentation to measure the apparent stiffness of epithelial monolayers reforming from dissociated cells and examine which cellular processes give rise to tissue-scale mechanics. We show that the formation of intercellular junctions coincided with an increase in the apparent stiffness of reforming monolayers that reflected the generation of a tissue-level tension. Tension rapidly increased, reaching a maximum after 150?min, before settling to a lower level over the next 3?h as monolayers established homeostasis. The emergence of tissue tension correlated with the formation of adherens junctions but not desmosomes. As a consequence, inhibition of any of the molecular mechanisms participating in adherens junction initiation, remodelling and maturation significantly impeded the emergence of tissue-level tension in monolayers. |Actins/metabolism [MESH] |Adherens Junctions/*metabolism [MESH] |Animals [MESH] |Cadherins/genetics/metabolism [MESH] |Cell Adhesion [MESH] |Cell Line [MESH] |Collagen Type I/metabolism [MESH] |Cytoskeleton/*metabolism [MESH] |Desmosomes/metabolism [MESH] |Dogs [MESH] |Elasticity Imaging Techniques [MESH] |Epithelium/*metabolism [MESH] |Gels/metabolism [MESH] |Humans [MESH] |Keratin-18/genetics/metabolism [MESH] |Microscopy, Atomic Force [MESH] |Morphogenesis [MESH]Formation of adherens junctions leads to the emergence of a tissue-lev(epmc).pdf DeepDyve Pubget Overpricing