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10.1016/j.ctrv.2014.04.003 http://scihub22266oqcxt.onion/10.1016/j.ctrv.2014.04.003 C4042838!4042838!24767837     free     free     free Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 229.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cancer+Treat+Rev 2014 ; 40 (6): 730-8 Nephropedia Template TP {{tp|p=24767837|t=2014. Recent Advances in Bone-Targeted Therapies of Metastatic Prostate Cancer |pdf=|usr=}}{{24767837}} gab.com Text Recent Advances in Bone-Targeted Therapies of Metastatic Prostate Cancer JO: Cancer Treat Rev http://www.kidney.de/pget.php?&tw=1&pmid=24767837 #FOAvip Prostate cancer is one of the most common malignancies affecting men worldwide, with bone being the most common site of metastasis in patients that progress beyond organ confinement. Bone metastases are virtually incurable and result in significant disease morbidity and mortality. Bone provides a unique microenvironment whose local interactions with tumor cells offer novel targets for therapeutic interventions. Several attractive molecules or pathways have been identified as new potential therapeutic targets for bone metastases caused by metastatic castration-resistant prostate cancer. In this review, we present the recent advances in molecular targeted therapies for prostate cancer bone metastasis focusing on therapies that target the bone cells and the bone microenvironment. The therapies covered in this review include agents that inhibit bone resorption, agents that stimulate bone formation, and agents that target the bone matrix. Suggestions to devise more effective molecular targeted therapies are proposed. Hopefully, with better understanding of the biology of the disease and the development of more robust targeted therapies, the survival and quality of life of the affected individuals could be significantly improved. Twit Text FOAVip Recent Advances in Bone-Targeted Therapies of Metastatic Prostate Cancer ????Cancer Treat Rev http://www.kidney.de/pget.php?&tw=1&pmid=24767837 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24767837 #FOAvip English Wikipedia <ref>{{Cite pmid|24767837}}</ref> Recent Advances in Bone-Targeted Therapies of Metastatic Prostate Cancer #MMPMID24767837 Deng X; He G; Liu J; Luo F; Peng X; Tang S; Gao Z; Lin Q; Keller JM; Yang T; Keller ET Cancer Treat Rev 2014[Jul]; 40 (6): 730-8 PMID24767837show ga Prostate cancer is one of the most common malignancies affecting men worldwide, with bone being the most common site of metastasis in patients that progress beyond organ confinement. Bone metastases are virtually incurable and result in significant disease morbidity and mortality. Bone provides a unique microenvironment whose local interactions with tumor cells offer novel targets for therapeutic interventions. Several attractive molecules or pathways have been identified as new potential therapeutic targets for bone metastases caused by metastatic castration-resistant prostate cancer. In this review, we present the recent advances in molecular targeted therapies for prostate cancer bone metastasis focusing on therapies that target the bone cells and the bone microenvironment. The therapies covered in this review include agents that inhibit bone resorption, agents that stimulate bone formation, and agents that target the bone matrix. Suggestions to devise more effective molecular targeted therapies are proposed. Hopefully, with better understanding of the biology of the disease and the development of more robust targeted therapies, the survival and quality of life of the affected individuals could be significantly improved. äRecent Advances in Bone-Targeted Therapies of Metastatic Prostate Canc(epmc).pdf DeepDyve Pubget Overpricing