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10.1111/ajt.12646 http://scihub22266oqcxt.onion/10.1111/ajt.12646 C4042397!4042397!24592880     free     free     free Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 225.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Transplant 2014 ; 14 (4): 952-9 Nephropedia Template TP {{tp|p=24592880|t=2014. Evidence for a Gene Controlling the Induction of Transplantation Tolerance |pdf=|usr=}}{{24592880}} gab.com Text Evidence for a Gene Controlling the Induction of Transplantation Tolerance JO: Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=24592880 #FOAvip Class I mismatched kidney transplantation in Massachusetts General Hospital MHC-defined miniature swine has been studied extensively as a model for induction of systemic allograft tolerance. In a large series of juvenile swine, long-term graft acceptance has been observed consistently following a 12-day course of cyclosporine. It was therefore surprising when three of five recipients in one of our studies rejected their grafts. Examination of the origins of the rejecting animals revealed that they were derived from a subline of the SLAdd miniature swine herd that was intentionally being inbred toward full homozygosity and had been inbred for eight generations prior to these experiments. A blinded study of additional class I mismatched renal transplants into animals from this subline confirmed the genetic basis of this rejection. We present here preliminary evidence suggesting that a likely explanation for this phenomenon is that the rejectors in this subline are homozygous for a recessive mutant allele of a gene normally involved in the induction of tolerance. Subsequent studies will be directed toward identification and characterization of the gene(s) involved, since existence of a similar genetic locus in humans might have implications for assessing an individual's likelihood of graft rejection versus tolerance induction prior to organ transplantation. Twit Text FOAVip Evidence for a Gene Controlling the Induction of Transplantation Tolerance ????Am J Transplant http://www.kidney.de/pget.php?&tw=1&pmid=24592880 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24592880 #FOAvip English Wikipedia <ref>{{Cite pmid|24592880}}</ref> Evidence for a Gene Controlling the Induction of Transplantation Tolerance #MMPMID24592880 Lee PW; Hanekamp JS; Villani V; Vagefi PA; Cina RA; Kamano C; O'Malley PE; Arn S; Yamada K; Sachs DH Am J Transplant 2014[Apr]; 14 (4): 952-9 PMID24592880show ga Class I mismatched kidney transplantation in Massachusetts General Hospital MHC-defined miniature swine has been studied extensively as a model for induction of systemic allograft tolerance. In a large series of juvenile swine, long-term graft acceptance has been observed consistently following a 12-day course of cyclosporine. It was therefore surprising when three of five recipients in one of our studies rejected their grafts. Examination of the origins of the rejecting animals revealed that they were derived from a subline of the SLAdd miniature swine herd that was intentionally being inbred toward full homozygosity and had been inbred for eight generations prior to these experiments. A blinded study of additional class I mismatched renal transplants into animals from this subline confirmed the genetic basis of this rejection. We present here preliminary evidence suggesting that a likely explanation for this phenomenon is that the rejectors in this subline are homozygous for a recessive mutant allele of a gene normally involved in the induction of tolerance. Subsequent studies will be directed toward identification and characterization of the gene(s) involved, since existence of a similar genetic locus in humans might have implications for assessing an individual's likelihood of graft rejection versus tolerance induction prior to organ transplantation. äEvidence for a Gene Controlling the Induction of Transplantation Toler(epmc).pdf DeepDyve Pubget Overpricing