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10.1016/j.freeradbiomed.2014.03.025 http://scihub22266oqcxt.onion/10.1016/j.freeradbiomed.2014.03.025 C4042208!4042208 !24681256     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 245.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24681256 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Free+Radic+Biol+Med 2014 ; 71 (ä): 196-207 Nephropedia Template TP {{tp|p=24681256 |t=2014. Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics |pdf=|usr=}}{{24681256 }} gab.com Text Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics JO: Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=24681256 #FOAvip Redox networks in the cell integrate signaling pathways that control metabolism, energetics, cell survival, and death. The physiological second messengers that modulate these pathways include nitric oxide, hydrogen peroxide, and electrophiles. Electrophiles are produced in the cell via both enzymatic and nonenzymatic lipid peroxidation and are also relatively abundant constituents of the diet. These compounds bind covalently to families of cysteine-containing, redox-sensing proteins that constitute the electrophile-responsive proteome, the subproteomes of which are found in localized intracellular domains. These include those proteins controlling responses to oxidative stress in the cytosol-notably the Keap1-Nrf2 pathway, the autophagy-lysosomal pathway, and proteins in other compartments including mitochondria and endoplasmic reticulum. The signaling pathways through which electrophiles function have unique characteristics that could be exploited for novel therapeutic interventions; however, development of such therapeutic strategies has been challenging due to a lack of basic understanding of the mechanisms controlling this form of redox signaling. In this review, we discuss current knowledge of the basic mechanisms of thiol-electrophile signaling and its potential impact on the translation of this important field of redox biology to the clinic. Emerging understanding of thiol-electrophile interactions and redox signaling suggests replacement of the oxidative stress hypothesis with a new redox biology paradigm, which provides an exciting and influential framework for guiding translational research. Twit Text FOAVip Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics ????Free Radic Biol Med http://www.kidney.de/pget.php?&tw=1&pmid=24681256 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24681256 #FOAvip English Wikipedia <ref>{{Cite pmid|24681256 }}</ref> Redox regulation of antioxidants, autophagy, and the response to stress: implications for electrophile therapeutics #MMPMID24681256 Levonen AL ; Hill BG ; Kansanen E ; Zhang J ; Darley-Usmar VM Free Radic Biol Med 2014[Jun]; 71 (ä): 196-207 PMID24681256 show ga Redox networks in the cell integrate signaling pathways that control metabolism, energetics, cell survival, and death. The physiological second messengers that modulate these pathways include nitric oxide, hydrogen peroxide, and electrophiles. Electrophiles are produced in the cell via both enzymatic and nonenzymatic lipid peroxidation and are also relatively abundant constituents of the diet. These compounds bind covalently to families of cysteine-containing, redox-sensing proteins that constitute the electrophile-responsive proteome, the subproteomes of which are found in localized intracellular domains. These include those proteins controlling responses to oxidative stress in the cytosol-notably the Keap1-Nrf2 pathway, the autophagy-lysosomal pathway, and proteins in other compartments including mitochondria and endoplasmic reticulum. The signaling pathways through which electrophiles function have unique characteristics that could be exploited for novel therapeutic interventions; however, development of such therapeutic strategies has been challenging due to a lack of basic understanding of the mechanisms controlling this form of redox signaling. In this review, we discuss current knowledge of the basic mechanisms of thiol-electrophile signaling and its potential impact on the translation of this important field of redox biology to the clinic. Emerging understanding of thiol-electrophile interactions and redox signaling suggests replacement of the oxidative stress hypothesis with a new redox biology paradigm, which provides an exciting and influential framework for guiding translational research. |Aldehydes/metabolism [MESH] |Animals [MESH] |Antioxidants/*metabolism/therapeutic use [MESH] |Autophagy/*genetics [MESH] |Gene Expression Regulation [MESH] |Heat-Shock Proteins/genetics/metabolism [MESH] |Humans [MESH] |Hydrogen Peroxide/metabolism [MESH] |Intracellular Signaling Peptides and Proteins/genetics/metabolism [MESH] |Kelch-Like ECH-Associated Protein 1 [MESH] |NF-E2-Related Factor 2/genetics/metabolism [MESH] |Nitric Oxide/metabolism [MESH] |Oxidative Stress/drug effects/*genetics [MESH] |Reactive Oxygen Species/metabolism [MESH] |Signal Transduction [MESH]Redox regulation of antioxidants, autophagy, and the response to stres(epmc).pdf DeepDyve Pubget Overpricing