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10.1016/j.devcel.2014.01.022 http://scihub22266oqcxt.onion/10.1016/j.devcel.2014.01.022 C4042153!4042153 !24697898     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24697898 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Dev+Cell 2014 ; 28 (6 ): 647-58 Nephropedia Template TP {{tp|p=24697898 |t=2014. PI3K class II ? controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function |pdf=|usr=}}{{24697898 }} gab.com Text PI3K class II controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function JO: Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=24697898 #FOAvip Multiple phosphatidylinositol (PtdIns) 3-kinases (PI3Ks) can produce PtdIns3P to control endocytic trafficking, but whether enzyme specialization occurs in defined subcellular locations is unclear. Here, we report that PI3K-C2? is enriched in the pericentriolar recycling endocytic compartment (PRE) at the base of the primary cilium, where it regulates production of a specific pool of PtdIns3P. Loss of PI3K-C2?-derived PtdIns3P leads to mislocalization of PRE markers such as TfR and Rab11, reduces Rab11 activation, and blocks accumulation of Rab8 at the primary cilium. These changes in turn cause defects in primary cilium elongation, Smo ciliary translocation, and Sonic Hedgehog (Shh) signaling and ultimately impair embryonic development. Selective reconstitution of PtdIns3P levels in cells lacking PI3K-C2? rescues Rab11 activation, primary cilium length, and Shh pathway induction. Thus, PI3K-C2? regulates the formation of a PtdIns3P pool at the PRE required for Rab11 and Shh pathway activation. Twit Text FOAVip PI3K class II controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function ????Dev Cell http://www.kidney.de/pget.php?&tw=1&pmid=24697898 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24697898 #FOAvip English Wikipedia <ref>{{Cite pmid|24697898 }}</ref> PI3K class II ? controls spatially restricted endosomal PtdIns3P and Rab11 activation to promote primary cilium function #MMPMID24697898 Franco I ; Gulluni F ; Campa CC ; Costa C ; Margaria JP ; Ciraolo E ; Martini M ; Monteyne D ; De Luca E ; Germena G ; Posor Y ; Maffucci T ; Marengo S ; Haucke V ; Falasca M ; Perez-Morga D ; Boletta A ; Merlo GR ; Hirsch E Dev Cell 2014[Mar]; 28 (6 ): 647-58 PMID24697898 show ga Multiple phosphatidylinositol (PtdIns) 3-kinases (PI3Ks) can produce PtdIns3P to control endocytic trafficking, but whether enzyme specialization occurs in defined subcellular locations is unclear. Here, we report that PI3K-C2? is enriched in the pericentriolar recycling endocytic compartment (PRE) at the base of the primary cilium, where it regulates production of a specific pool of PtdIns3P. Loss of PI3K-C2?-derived PtdIns3P leads to mislocalization of PRE markers such as TfR and Rab11, reduces Rab11 activation, and blocks accumulation of Rab8 at the primary cilium. These changes in turn cause defects in primary cilium elongation, Smo ciliary translocation, and Sonic Hedgehog (Shh) signaling and ultimately impair embryonic development. Selective reconstitution of PtdIns3P levels in cells lacking PI3K-C2? rescues Rab11 activation, primary cilium length, and Shh pathway induction. Thus, PI3K-C2? regulates the formation of a PtdIns3P pool at the PRE required for Rab11 and Shh pathway activation. |Animals [MESH] |Cell Movement/*physiology [MESH] |Cells, Cultured [MESH] |Cilia/*physiology [MESH] |Embryo, Mammalian/cytology/metabolism [MESH] |Endosomes/*metabolism [MESH] |Female [MESH] |Fibroblasts/cytology/metabolism [MESH] |Immunoblotting [MESH] |Immunoprecipitation [MESH] |Male [MESH] |Mice [MESH] |Mice, Inbred C57BL [MESH] |Mice, Knockout [MESH] |Phosphatidylinositol 3-Kinases/*physiology [MESH] |Phosphatidylinositol Phosphates/*metabolism [MESH] |Phosphoinositide-3 Kinase Inhibitors [MESH] |Protein Transport [MESH] |RNA, Small Interfering/genetics [MESH] |Receptors, G-Protein-Coupled/metabolism [MESH] |Receptors, Transferrin/metabolism [MESH] |Signal Transduction [MESH] |Smoothened Receptor [MESH]PI3K class II ? controls spatially restricted endosomal PtdIns3P and R(epmc).pdf DeepDyve Pubget Overpricing