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10.1152/ajpendo.00599.2013 http://scihub22266oqcxt.onion/10.1152/ajpendo.00599.2013 C4042099!4042099!24735892     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24735892&cmd=llinks): Failed to open stream: HTTP request failed! 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Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic ?-cell |pdf=|usr=}}{{24735892}} gab.com Text Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic -cell JO: Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=24735892 #FOAvip Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with the activation of glucagon-producing ?-cells. We therefore hypothesized that neuronostatin could influence glucose homeostasis via a direct effect on the ?-cell. Neuronostatin enhanced low-glucose-induced glucagon release in isolated rat islets and in the immortalized ?-cell line ?TC1-9. Furthermore, incubation with neuronostatin led to an increase in transcription of glucagon mRNA, as determined by RT-PCR. Neuronostatin also inhibited glucose-stimulated insulin secretion from isolated islets. However, neuronostatin did not alter insulin release from the ?-cell line INS 832/13, indicating that the effect of neuronostatin on insulin secretion may be secondary to a direct action on the ?-cell. In agreement with our in vitro data, intra-arterial infusion of neuronostatin in male rats delayed glucose disposal and inhibited insulin release during a glucose challenge. These studies suggest that neuronostatin participates in maintaining glucose homeostasis through cell-cell interactions between ?-cells and ?-cells in the endocrine pancreas, leading to attenuation in insulin secretion. Twit Text FOAVip Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic -cell ????Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=24735892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24735892 #FOAvip English Wikipedia <ref>{{Cite pmid|24735892}}</ref> Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic ?-cell #MMPMID24735892 Salvatori AS; Elrick MM; Samson WK; Corbett JA; Yosten GLC Am J Physiol Endocrinol Metab 2014[Jun]; 306 (11): E1257-63 PMID24735892show ga Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with the activation of glucagon-producing ?-cells. We therefore hypothesized that neuronostatin could influence glucose homeostasis via a direct effect on the ?-cell. Neuronostatin enhanced low-glucose-induced glucagon release in isolated rat islets and in the immortalized ?-cell line ?TC1-9. Furthermore, incubation with neuronostatin led to an increase in transcription of glucagon mRNA, as determined by RT-PCR. Neuronostatin also inhibited glucose-stimulated insulin secretion from isolated islets. However, neuronostatin did not alter insulin release from the ?-cell line INS 832/13, indicating that the effect of neuronostatin on insulin secretion may be secondary to a direct action on the ?-cell. In agreement with our in vitro data, intra-arterial infusion of neuronostatin in male rats delayed glucose disposal and inhibited insulin release during a glucose challenge. These studies suggest that neuronostatin participates in maintaining glucose homeostasis through cell-cell interactions between ?-cells and ?-cells in the endocrine pancreas, leading to attenuation in insulin secretion. äNeuronostatin inhibits glucose-stimulated insulin secretion via direct(epmc).pdf DeepDyve Pubget Overpricing