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10.1152/ajpendo.00599.2013 http://scihub22266oqcxt.onion/10.1152/ajpendo.00599.2013 C4042099!4042099 !24735892     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24735892 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Am+J+Physiol+Endocrinol+Metab 2014 ; 306 (11 ): E1257-63 Nephropedia Template TP {{tp|p=24735892 |t=2014. Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic ?-cell |pdf=|usr=}}{{24735892 }} gab.com Text Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic -cell JO: Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=24735892 #FOAvip Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with the activation of glucagon-producing ?-cells. We therefore hypothesized that neuronostatin could influence glucose homeostasis via a direct effect on the ?-cell. Neuronostatin enhanced low-glucose-induced glucagon release in isolated rat islets and in the immortalized ?-cell line ?TC1-9. Furthermore, incubation with neuronostatin led to an increase in transcription of glucagon mRNA, as determined by RT-PCR. Neuronostatin also inhibited glucose-stimulated insulin secretion from isolated islets. However, neuronostatin did not alter insulin release from the ?-cell line INS 832/13, indicating that the effect of neuronostatin on insulin secretion may be secondary to a direct action on the ?-cell. In agreement with our in vitro data, intra-arterial infusion of neuronostatin in male rats delayed glucose disposal and inhibited insulin release during a glucose challenge. These studies suggest that neuronostatin participates in maintaining glucose homeostasis through cell-cell interactions between ?-cells and ?-cells in the endocrine pancreas, leading to attenuation in insulin secretion. Twit Text FOAVip Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic -cell ????Am J Physiol Endocrinol Metab http://www.kidney.de/pget.php?&tw=1&pmid=24735892 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24735892 #FOAvip English Wikipedia <ref>{{Cite pmid|24735892 }}</ref> Neuronostatin inhibits glucose-stimulated insulin secretion via direct action on the pancreatic ?-cell #MMPMID24735892 Salvatori AS ; Elrick MM ; Samson WK ; Corbett JA ; Yosten GL Am J Physiol Endocrinol Metab 2014[Jun]; 306 (11 ): E1257-63 PMID24735892 show ga Neuronostatin is a recently described peptide hormone encoded by the somatostatin gene. We previously showed that intraperitoneal injection of neuronostatin into mice resulted in c-Jun accumulation in pancreatic islets in a pattern consistent with the activation of glucagon-producing ?-cells. We therefore hypothesized that neuronostatin could influence glucose homeostasis via a direct effect on the ?-cell. Neuronostatin enhanced low-glucose-induced glucagon release in isolated rat islets and in the immortalized ?-cell line ?TC1-9. Furthermore, incubation with neuronostatin led to an increase in transcription of glucagon mRNA, as determined by RT-PCR. Neuronostatin also inhibited glucose-stimulated insulin secretion from isolated islets. However, neuronostatin did not alter insulin release from the ?-cell line INS 832/13, indicating that the effect of neuronostatin on insulin secretion may be secondary to a direct action on the ?-cell. In agreement with our in vitro data, intra-arterial infusion of neuronostatin in male rats delayed glucose disposal and inhibited insulin release during a glucose challenge. These studies suggest that neuronostatin participates in maintaining glucose homeostasis through cell-cell interactions between ?-cells and ?-cells in the endocrine pancreas, leading to attenuation in insulin secretion. |Animals [MESH] |Area Under Curve [MESH] |Blood Glucose/metabolism [MESH] |Blotting, Western [MESH] |Bradykinin/pharmacology [MESH] |Cell Line [MESH] |Cyclic AMP-Dependent Protein Kinases/metabolism [MESH] |Cyclic AMP/metabolism [MESH] |Electrophoresis, Polyacrylamide Gel [MESH] |Glucagon-Secreting Cells/drug effects/*metabolism [MESH] |Glucose/*antagonists & inhibitors/*pharmacology [MESH] |Injections, Intraperitoneal [MESH] |Inositol 1,4,5-Trisphosphate/metabolism [MESH] |Insulin/blood/*metabolism [MESH] |Islets of Langerhans/drug effects/metabolism [MESH] |Male [MESH] |Peptide Fragments/administration & dosage/*pharmacology [MESH] |Rats [MESH] |Rats, Sprague-Dawley [MESH] |Real-Time Polymerase Chain Reaction [MESH]Neuronostatin inhibits glucose-stimulated insulin secretion via direct(epmc).pdf DeepDyve Pubget Overpricing