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10.1016/j.molmed.2014.02.004

http://scihub22266oqcxt.onion/10.1016/j.molmed.2014.02.004
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C4041816!4041816!24636942
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suck abstract from ncbi


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pmid24636942      Trends+Mol+Med 2014 ; 20 (6): 353-62
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  • The junctophilin family of proteins: From bench to bedside #MMPMID24636942
  • Landstrom AP; Beavers DL; Wehrens XH
  • Trends Mol Med 2014[Jun]; 20 (6): 353-62 PMID24636942show ga
  • Excitable tissues rely on junctional membrane complexes to couple cell surface signals to intracellular channels. The junctophilins have emerged as a family of proteins critical in coordinating the maturation and maintenance of this cellular ultrastructure. Within skeletal and cardiac muscle, junctophilin-1 and junctophilin-2, respectively, couple sarcolemmal and intracellular calcium channels. In neuronal tissue, junctophilin 3 and junctophilin 4 may have an emerging role in coupling membrane neurotransmitter receptors and intracellular calcium channels. These important physiologic roles are highlighted by the pathophysiology which results when these proteins are perturbed and a growing body of literature has associated junctophilins with the pathogenesis of human disease.
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