Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Trends+Mol+Med 2014 ; 20 (6): 353-62 Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
The junctophilin family of proteins: From bench to bedside #MMPMID24636942
Landstrom AP; Beavers DL; Wehrens XH
Trends Mol Med 2014[Jun]; 20 (6): 353-62 PMID24636942show ga
Excitable tissues rely on junctional membrane complexes to couple cell surface signals to intracellular channels. The junctophilins have emerged as a family of proteins critical in coordinating the maturation and maintenance of this cellular ultrastructure. Within skeletal and cardiac muscle, junctophilin-1 and junctophilin-2, respectively, couple sarcolemmal and intracellular calcium channels. In neuronal tissue, junctophilin 3 and junctophilin 4 may have an emerging role in coupling membrane neurotransmitter receptors and intracellular calcium channels. These important physiologic roles are highlighted by the pathophysiology which results when these proteins are perturbed and a growing body of literature has associated junctophilins with the pathogenesis of human disease.