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10.1016/j.molmed.2014.03.001 http://scihub22266oqcxt.onion/10.1016/j.molmed.2014.03.001 C4041810!4041810!24698494     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24698494&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Mol+Med 2014 ; 20 (6): 343-52 Nephropedia Template TP {{tp|p=24698494|t=2014. Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis |pdf=|usr=}}{{24698494}} gab.com Text Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis JO: Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=24698494 #FOAvip The B cell lymphoma 6 (BCL6) transcriptional repressor is a master regulator of the germinal center (GC) B cell phenotype, required for their unique proliferative and stress tolerant phenotype. Most B cell lymphomas arise from GC B cells and are dependent on the continued or deregulated expression of BCL6 to maintain their survival. The actions of BCL6 in B cells involve formation of distinct chromatin modifying complexes that silence specific promoter and enhancer networks, respectively. The same biochemical mechanisms are maintained in malignant lymphoma cells. Targeted inhibition of these BCL6 functions has emerged as the basis for rational design of lymphoma therapies and combinatorial regimens. In this review, we summarize recent advances on BCL6 mechanisms of action and the deregulation of its target gene networks in lymphoma. Twit Text FOAVip Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis ????Trends Mol Med http://www.kidney.de/pget.php?&tw=1&pmid=24698494 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24698494 #FOAvip English Wikipedia <ref>{{Cite pmid|24698494}}</ref> Breaking bad in the germinal center: how deregulation of BCL6 contributes to lymphomagenesis #MMPMID24698494 Hatzi K; Melnick A Trends Mol Med 2014[Jun]; 20 (6): 343-52 PMID24698494show ga The B cell lymphoma 6 (BCL6) transcriptional repressor is a master regulator of the germinal center (GC) B cell phenotype, required for their unique proliferative and stress tolerant phenotype. Most B cell lymphomas arise from GC B cells and are dependent on the continued or deregulated expression of BCL6 to maintain their survival. The actions of BCL6 in B cells involve formation of distinct chromatin modifying complexes that silence specific promoter and enhancer networks, respectively. The same biochemical mechanisms are maintained in malignant lymphoma cells. Targeted inhibition of these BCL6 functions has emerged as the basis for rational design of lymphoma therapies and combinatorial regimens. In this review, we summarize recent advances on BCL6 mechanisms of action and the deregulation of its target gene networks in lymphoma. äBreaking bad in the germinal center: how deregulation of BCL6 contribu(epmc).pdf DeepDyve Pubget Overpricing