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10.1016/j.ajog.2014.01.024 http://scihub22266oqcxt.onion/10.1016/j.ajog.2014.01.024 C4041388!4041388 !24440566     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24440566 &cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215       Am+J+Obstet+Gynecol 2014 ; 210 (6 ): 547.e1-7 Nephropedia Template TP {{tp|p=24440566 |t=2014. Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia |pdf=|usr=}}{{24440566 }} gab.com Text Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia JO: Am J Obstet Gynecol http://www.kidney.de/pget.php?&tw=1&pmid=24440566 #FOAvip OBJECTIVE: Soluble fms-like tyrosine kinase (sFlt-1) is an important mediator in the pathogenesis of preeclampsia. We sought to determine whether platelet-monocyte aggregates (PMAs) produced sFlt-1 and whether PMAs contributed to sFlt-1 production in preeclampsia. STUDY DESIGN: This was a case-control study of sFlt-1 release from PMAs using blood samples from women with preeclampsia matched by gestational age to pregnant controls. A third group of nonpregnant, reproductive-age women comprised an additional control group. Experiments were also performed using blood from nonpregnant women to elucidate whether inducing PMAs could stimulate sFlt-1 production and, if so, to determine the necessary receptors and pathways. RESULTS: Women with preeclampsia had increased total Flt-1 concentrations in platelets and monocytes at baseline compared with pregnant controls (25 vs 10 pg/mL, P = .0003). sFlt-1 production was elicited from monocytes incubated with thrombin-activated platelets from nonpregnant women. sFlt-1 production was regulated at the transcriptional level by p38 and nuclear factor-?B-dependent pathways. CONCLUSION: Activated platelets in preeclampsia bind monocytes to generate sFlt-1. PMAs are a previously unrecognized source of sFlt-1 that may contribute to endothelial dysfunction and systemic inflammation commonly observed in preeclampsia. Twit Text FOAVip Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia ????Am J Obstet Gynecol http://www.kidney.de/pget.php?&tw=1&pmid=24440566 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24440566 #FOAvip English Wikipedia <ref>{{Cite pmid|24440566 }}</ref> Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the pathogenesis of preeclampsia #MMPMID24440566 Major HD ; Campbell RA ; Silver RM ; Branch DW ; Weyrich AS Am J Obstet Gynecol 2014[Jun]; 210 (6 ): 547.e1-7 PMID24440566 show ga OBJECTIVE: Soluble fms-like tyrosine kinase (sFlt-1) is an important mediator in the pathogenesis of preeclampsia. We sought to determine whether platelet-monocyte aggregates (PMAs) produced sFlt-1 and whether PMAs contributed to sFlt-1 production in preeclampsia. STUDY DESIGN: This was a case-control study of sFlt-1 release from PMAs using blood samples from women with preeclampsia matched by gestational age to pregnant controls. A third group of nonpregnant, reproductive-age women comprised an additional control group. Experiments were also performed using blood from nonpregnant women to elucidate whether inducing PMAs could stimulate sFlt-1 production and, if so, to determine the necessary receptors and pathways. RESULTS: Women with preeclampsia had increased total Flt-1 concentrations in platelets and monocytes at baseline compared with pregnant controls (25 vs 10 pg/mL, P = .0003). sFlt-1 production was elicited from monocytes incubated with thrombin-activated platelets from nonpregnant women. sFlt-1 production was regulated at the transcriptional level by p38 and nuclear factor-?B-dependent pathways. CONCLUSION: Activated platelets in preeclampsia bind monocytes to generate sFlt-1. PMAs are a previously unrecognized source of sFlt-1 that may contribute to endothelial dysfunction and systemic inflammation commonly observed in preeclampsia. |Adult [MESH] |Blood Platelets/*metabolism [MESH] |Case-Control Studies [MESH] |Cell Culture Techniques [MESH] |Enzyme-Linked Immunosorbent Assay [MESH] |Female [MESH] |Humans [MESH] |MAP Kinase Signaling System/*physiology [MESH] |Monocytes/*metabolism [MESH] |NF-kappa B/*antagonists & inhibitors [MESH] |P-Selectin/analysis [MESH] |Platelet Aggregation/*physiology [MESH] |Pre-Eclampsia/*metabolism [MESH] |Pregnancy [MESH] |RNA, Messenger/biosynthesis [MESH]Synthesis of sFlt-1 by platelet-monocyte aggregates contributes to the(epmc).pdf DeepDyve Pubget Overpricing