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10.1146/annurev-physiol-030212-183811 http://scihub22266oqcxt.onion/10.1146/annurev-physiol-030212-183811 C4041114!4041114!23020579     free     free     free       Annu+Rev+Physiol 2013 ; 75 (ä): 181-200 Nephropedia Template TP {{tp|p=23020579|t=2013. TRPA1: A Gatekeeper for Inflammation |pdf=|usr=}}{{23020579}} gab.com Text TRPA1: A Gatekeeper for Inflammation JO: Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23020579 #FOAvip Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli, tissue repair, and protective behaviors to prevent further damage and encourage healing. However, inflammation may outlive its usefulness and become chronic. Chronic inflammation can lead to a host of diseases, including asthma, itch, rheumatoid arthritis, and colitis. Primary afferent sensory neurons that innervate target organs release inflammatory neuropeptides in the local area of tissue damage to promote vascular leakage, the recruitment of immune cells, and hypersensitivity to mechanical and thermal stimuli. TRPA1 channels are required for neuronal excitation, the release of inflammatory neuropeptides, and subsequent pain hypersensitivity. TRPA1 is also activated by the release of inflammatory agents from nonneuronal cells in the area of tissue injury or disease. This dual function of TRPA1 as a detector and instigator of inflammatory agents makes TRPA1 a gatekeeper of chronic inflammatory disorders of the skin, airways, and gastrointestinal tract. Twit Text FOAVip TRPA1: A Gatekeeper for Inflammation ????Annu Rev Physiol http://www.kidney.de/pget.php?&tw=1&pmid=23020579 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=23020579 #FOAvip English Wikipedia <ref>{{Cite pmid|23020579}}</ref> TRPA1: A Gatekeeper for Inflammation #MMPMID23020579 Bautista DM; Pellegrino M; Tsunozaki M Annu Rev Physiol 2013[]; 75 (ä): 181-200 PMID23020579show ga Tissue damage evokes an inflammatory response that promotes the removal of harmful stimuli, tissue repair, and protective behaviors to prevent further damage and encourage healing. However, inflammation may outlive its usefulness and become chronic. Chronic inflammation can lead to a host of diseases, including asthma, itch, rheumatoid arthritis, and colitis. Primary afferent sensory neurons that innervate target organs release inflammatory neuropeptides in the local area of tissue damage to promote vascular leakage, the recruitment of immune cells, and hypersensitivity to mechanical and thermal stimuli. TRPA1 channels are required for neuronal excitation, the release of inflammatory neuropeptides, and subsequent pain hypersensitivity. TRPA1 is also activated by the release of inflammatory agents from nonneuronal cells in the area of tissue injury or disease. This dual function of TRPA1 as a detector and instigator of inflammatory agents makes TRPA1 a gatekeeper of chronic inflammatory disorders of the skin, airways, and gastrointestinal tract. äTRPA1: A Gatekeeper for Inflammation (epmc).pdf DeepDyve Pubget Overpricing