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10.1146/annurev-genom-091212-153520

http://scihub22266oqcxt.onion/10.1146/annurev-genom-091212-153520
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C4040957!4040957!23724904
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suck abstract from ncbi


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pmid23724904      Annu+Rev+Genomics+Hum+Genet 2013 ; 14 (ä): 441-65
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  • The Power of Meta-Analysis in Genome Wide Association Studies #MMPMID23724904
  • Panagiotou OA; Willer CJ; Hirschhorn JN; Ioannidis JPA
  • Annu Rev Genomics Hum Genet 2013[]; 14 (ä): 441-65 PMID23724904show ga
  • Meta-analysis of multiple genome-wide association (GWA) studies has become common practice over the last few years. The main advantage of this technique is the maximization of power to detect the subtle genetic effects for common traits. Moreover, one can use meta-analysis to probe and identify heterogeneity in the effect sizes across the combined studies. In this review we systematically appraised and evaluated the characteristics of GWA meta-analyses with 10,000 or more subjects published until June 2012. We overview the current landscape of variants discovered by GWA meta-analyses and we discuss and assess with extrapolations from empirical data the value of larger meta-analyses for the discovery of additional genetic associations and new biology in the future. Finally, we discuss some emerging logistical and practical issues related to the conduct of meta-analysis of GWA studies.
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