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10.3324/haematol.2013.087205 http://scihub22266oqcxt.onion/10.3324/haematol.2013.087205 C4040909!4040909 !24700491     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24700491 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Haematologica 2014 ; 99 (6 ): 1050-61 Nephropedia Template TP {{tp|p=24700491 |t=2014. Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice |pdf=|usr=}}{{24700491 }} gab.com Text Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice JO: Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=24700491 #FOAvip Novel therapies are needed for pediatric acute lymphoblastic leukemia resistant to conventional therapy. While emerging data suggest leukemias as possible targets of oncolytic attenuated measles virus, it is unknown whether measles virus can eradicate disseminated leukemia, in particular pediatric acute lymphoblastic leukemia. We evaluated the efficacy of attenuated measles virus against a large panel of pediatric xenografted and native primary acute lymphoblastic leukemias ex vivo, and against four different acute lymphoblastic leukemia xenografts of B-lineage in non-obese diabetic/severe combined immunodeficient mice. Ex vivo, attenuated measles virus readily spread among and effectively killed leukemia cells while sparing normal human blood cells and their progenitors. In immunodeficient mice with disseminated acute lymphoblastic leukemia a few intravenous injections of attenuated measles virus sufficed to eradicate leukemic blasts in the hematopoietic system and to control central nervous system disease resulting in long-term survival in three of the four xenografted B-lineage leukemias. Differential sensitivity of leukemia cells did not require increased expression of the measles entry receptors CD150 or CD46 nor absence of the anti-viral retinoic acid-inducible gene I/melanoma differentiation associated gene-5 /interferon pathway. Attenuated oncolytic measles virus is dramatically effective against pediatric B-lineage acute lymphoblastic leukemia in the pre-clinical setting warranting further investigations towards clinical translation. Twit Text FOAVip Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice ????Haematologica http://www.kidney.de/pget.php?&tw=1&pmid=24700491 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24700491 #FOAvip English Wikipedia <ref>{{Cite pmid|24700491 }}</ref> Attenuated measles virus controls pediatric acute B-lineage lymphoblastic leukemia in NOD/SCID mice #MMPMID24700491 Lühl NC ; Zirngibl F ; Dorneburg C ; Wei J ; Dahlhaus M ; Barth TF ; Meyer LH ; Queudeville M ; Eckhoff S ; Debatin KM ; Beltinger C Haematologica 2014[Jun]; 99 (6 ): 1050-61 PMID24700491 show ga Novel therapies are needed for pediatric acute lymphoblastic leukemia resistant to conventional therapy. While emerging data suggest leukemias as possible targets of oncolytic attenuated measles virus, it is unknown whether measles virus can eradicate disseminated leukemia, in particular pediatric acute lymphoblastic leukemia. We evaluated the efficacy of attenuated measles virus against a large panel of pediatric xenografted and native primary acute lymphoblastic leukemias ex vivo, and against four different acute lymphoblastic leukemia xenografts of B-lineage in non-obese diabetic/severe combined immunodeficient mice. Ex vivo, attenuated measles virus readily spread among and effectively killed leukemia cells while sparing normal human blood cells and their progenitors. In immunodeficient mice with disseminated acute lymphoblastic leukemia a few intravenous injections of attenuated measles virus sufficed to eradicate leukemic blasts in the hematopoietic system and to control central nervous system disease resulting in long-term survival in three of the four xenografted B-lineage leukemias. Differential sensitivity of leukemia cells did not require increased expression of the measles entry receptors CD150 or CD46 nor absence of the anti-viral retinoic acid-inducible gene I/melanoma differentiation associated gene-5 /interferon pathway. Attenuated oncolytic measles virus is dramatically effective against pediatric B-lineage acute lymphoblastic leukemia in the pre-clinical setting warranting further investigations towards clinical translation. |Animals [MESH] |Antigens, CD/metabolism [MESH] |Cell Line, Tumor [MESH] |Cell Survival [MESH] |Child [MESH] |Cytopathogenic Effect, Viral [MESH] |Disease Models, Animal [MESH] |Genetic Vectors/administration & dosage/*genetics [MESH] |Humans [MESH] |Measles virus/*genetics [MESH] |Membrane Cofactor Protein/metabolism [MESH] |Membrane Proteins/metabolism [MESH] |Mice, Inbred NOD [MESH] |Mice, SCID [MESH] |Nerve Tissue Proteins/metabolism [MESH] |Oncolytic Virotherapy [MESH] |Oncolytic Viruses/*genetics [MESH] |Precursor B-Cell Lymphoblastic Leukemia-Lymphoma/*genetics/metabolism/mortality/pathology/therapy [MESH] |Receptors, Cell Surface/metabolism [MESH] |Signaling Lymphocytic Activation Molecule Family Member 1 [MESH] |Transcription, Genetic [MESH] |Virus Replication [MESH]Attenuated measles virus controls pediatric acute B-lineage lymphoblas(epmc).pdf DeepDyve Pubget Overpricing