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10.1038/cddis.2013.547 http://scihub22266oqcxt.onion/10.1038/cddis.2013.547 C4040701!4040701!24481454     free     free     free Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=24481454&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Cell+Death+Dis 2014 ; 5 (1): e1040- Nephropedia Template TP {{tp|p=24481454|t=2014. Zinc depletion regulates the processing and secretion of IL-1? |pdf=|usr=}}{{24481454}} gab.com Text Zinc depletion regulates the processing and secretion of IL-1 JO: Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=24481454 #FOAvip Sterile inflammation contributes to many common and serious human diseases. The pro-inflammatory cytokine interleukin-1? (IL-1?) drives sterile inflammatory responses and is thus a very attractive therapeutic target. Activation of IL-1? in sterile diseases commonly requires an intracellular multi-protein complex called the NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome. A number of disease-associated danger molecules are known to activate the NLRP3 inflammasome. We show here that depletion of zinc from macrophages, a paradigm for zinc deficiency, also activates the NLRP3 inflammasome and induces IL-1? secretion. Our data suggest that zinc depletion damages the integrity of lysosomes and that this event is important for NLRP3 activation. These data provide new mechanistic insight to how zinc deficiency contributes to inflammation and further unravel the mechanisms of NLRP3 inflammasome activation. Twit Text FOAVip Zinc depletion regulates the processing and secretion of IL-1 ????Cell Death Dis http://www.kidney.de/pget.php?&tw=1&pmid=24481454 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24481454 #FOAvip English Wikipedia <ref>{{Cite pmid|24481454}}</ref> Zinc depletion regulates the processing and secretion of IL-1? #MMPMID24481454 Summersgill H; England H; Lopez-Castejon G; Lawrence CB; Luheshi NM; Pahle J; Mendes P; Brough D Cell Death Dis 2014[Jan]; 5 (1): e1040- PMID24481454show ga Sterile inflammation contributes to many common and serious human diseases. The pro-inflammatory cytokine interleukin-1? (IL-1?) drives sterile inflammatory responses and is thus a very attractive therapeutic target. Activation of IL-1? in sterile diseases commonly requires an intracellular multi-protein complex called the NLRP3 (NACHT, LRR, and PYD domains-containing protein 3) inflammasome. A number of disease-associated danger molecules are known to activate the NLRP3 inflammasome. We show here that depletion of zinc from macrophages, a paradigm for zinc deficiency, also activates the NLRP3 inflammasome and induces IL-1? secretion. Our data suggest that zinc depletion damages the integrity of lysosomes and that this event is important for NLRP3 activation. These data provide new mechanistic insight to how zinc deficiency contributes to inflammation and further unravel the mechanisms of NLRP3 inflammasome activation. äZinc depletion regulates the processing and secretion of IL-1? (epmc).pdf DeepDyve Pubget Overpricing