Warning: file_get_contents(https://eutils.ncbi.nlm.nih.gov/entrez/eutils/elink.fcgi?dbfrom=pubmed&id=23702776
&cmd=llinks): Failed to open stream: HTTP request failed! HTTP/1.1 429 Too Many Requests
in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 215
SWI/SNF chromatin remodeling enzymes are associated with cardiac hypertrophy in a
genetic rat model of hypertension
#MMPMID23702776
Mehrotra A
; Joe B
; de la Serna IL
J Cell Physiol
2013[Dec]; 228
(12
): 2337-42
PMID23702776
show ga
Pathological cardiac hypertrophy is characterized by a sustained increase in
cardiomyocyte size and re-activation of the fetal cardiac gene program. Previous
studies implicated SWI/SNF chromatin remodeling enzymes as regulators of the
fetal cardiac gene program in surgical models of cardiac hypertrophy. Although
hypertension is a common risk factor for developing cardiac hypertrophy, there
has not yet been any investigation into the role of SWI/SNF enzymes in cardiac
hypertrophy using genetic models of hypertension. In this study, we tested the
hypothesis that components of the SWI/SNF complex are activated and recruited to
promoters that regulate the fetal cardiac gene program in hearts that become
hypertrophic as a result of salt induced hypertension. Utilizing the Dahl
salt-sensitive (S) rat model, we found that the protein levels of several SWI/SNF
subunits required for heart development, Brg1, Baf180, and Baf60c, are elevated
in hypertrophic hearts from S rats fed a high salt diet compared with
normotensive hearts from Dahl salt-resistant (R) rats fed the same diet.
Furthermore, we detected significantly higher levels of SWI/SNF subunit
enrichment as well as evidence of more accessible chromatin structure on two
fetal cardiac gene promoters in hearts from S rats compared with R rats. Our data
implicate SWI/SNF chromatin remodeling enzymes as regulators of gene expression
in cardiac hypertrophy resulting from salt induced hypertension. Thus we provide
novel insights into the epigenetic mechanisms by which salt induced hypertension
leads to cardiac hypertrophy.
|Animals
[MESH]
|Cardiomegaly/genetics/*physiopathology
[MESH]
|Chromatin Assembly and Disassembly/genetics/*physiology
[MESH]
free
free
free
