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2014 ; 39
(3
): 467-71
Nephropedia Template TP
gab.com Text
Twit Text FOAVip
Twit Text #
English Wikipedia
Revisiting morphine-augmented hepatobiliary imaging for diagnosing acute
cholecystitis: the potential pitfall of high false positive rate
#MMPMID24402474
Hung BT
; Traylor KS
; Wong CY
Abdom Imaging
2014[Jun]; 39
(3
): 467-71
PMID24402474
show ga
PURPOSE: The aim of this retrospective study was to investigate the efficacy of
morphine-augmented hepatobiliary imaging (MAHBI) for diagnosing acute
cholecystitis (AC). METHODS: Sixty-eight patients (Male:Female = 36:32, age = 54
± 17 years) referred for diagnosis of AC by 30-min post-morphine MAHBI after the
standard 1-h imaging were recruited. Non-visualization of gallbladder on 30-min
post-morphine images by visual analysis was considered positive. Final diagnosis
of pathological examination for all patients was used as the gold standard.
RESULTS: There was significant correlation of AC and MAHBI (p < 0.05). There were
45 true positive (TP), 19 false positive (FP), 4 true negative (TN), and no false
negative (FN) cases using gallbladder visualization by 30-min post-morphine as
the criteria, with a high false positive rate of 83%. The sensitivity,
specificity, accuracy, positive and negative predictive values of MAHBI in
detecting AC were 100%, 17%, 72%, 70%, and 100%, respectively. CONCLUSIONS: MAHBI
is sensitive but may not specific for diagnosing AC due to the potential pitfall
of high false positive rate. Correlation with other clinical findings is
recommended for optimal patient management.