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2014 ; 14
(ä): 54
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Glass ionomer ART sealant and fluoride-releasing resin sealant in fissure caries
prevention--results from a randomized clinical trial
#MMPMID24886444
Liu BY
; Xiao Y
; Chu CH
; Lo EC
BMC Oral Health
2014[May]; 14
(ä): 54
PMID24886444
show ga
BACKGROUND: The relative performance of ART sealant and fluoride-releasing resin
sealant in preventing fissure caries in permanent molars was compared in a
randomized clinical trial conducted in southern China (ClinicalTrials.gov
NCT01829334). METHODS: After obtaining ethical approval, healthy schoolchildren
who had permanent first molars with occlusal fissures which were sound but deep
or presented with only incipient caries were recruited for the study. Included
molars were randomly allocated into one of four parallel study groups in units of
left/right teeth per mouth. Two of the four groups adopted the methods of ART or
fluoride-releasing resin sealant placement while the other two groups adopted the
topical fluoride application methods. Fissure status of the molars in each group
was evaluated every 6 months. Development of dentine caries and sealant retention
over 24 months in the molars in the two sealant-using groups was compared in this
report. Outcome on cost-effectiveness of all four groups over 36 months will be
reported elsewhere. RESULTS: At baseline, a total of 280 children (383 molars)
with mean age 7.8 years were involved for the two sealant groups. After 24
months, 261 children (357 molars) were followed. Proportions of molars with
dentine caries were 7.3% and 3.9% in the ART sealant and fluoride-releasing resin
sealant groups, respectively (chi-square test, p?=?0.171). Life-table survival
analysis showed that sealant retention (full and partial) rate over 24 months for
the resin sealant (73%) was significantly higher than that (50%) for the ART
sealant (p?0.001). Molar survival (no development of dentine caries) rates in
the ART sealant (93%) and fluoride-releasing resin sealant (96%) groups were not
significantly different (p?=?0.169). Multilevel logistic regression (GEE
modeling) accounting for the effects of data clustering and confounding factors
confirmed this finding. CONCLUSIONS: Though the retention of fluoride-releasing
resin sealant was better than that of the ART sealant, their effectiveness in
preventing fissure caries in permanent molars did not differ significantly over
24 months. ART sealants could be a good alternative when and where resources for
resin sealant placement are not readily available.