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10.1016/j.tig.2014.03.005 http://scihub22266oqcxt.onion/10.1016/j.tig.2014.03.005 C4039741!4039741!24794811     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Trends+Genet 2014 ; 30 (6): 245-53 Nephropedia Template TP {{tp|p=24794811|t=2014. Mechanisms of genome instability induced by RNA processing defects |pdf=|usr=}}{{24794811}} gab.com Text Mechanisms of genome instability induced by RNA processing defects JO: Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=24794811 #FOAvip The role of normal transcription and RNA processing in maintaining genome integrity is becoming increasingly appreciated in organisms ranging from bacteria to humans. Several mutations in RNA biogenesis factors have been implicated in human cancers, but the mechanisms and potential connections to tumor genome instability are not clear. Here we discuss how RNA processing defects could destabilize genomes through mutagenic R-loop structures and by altering expression of genes required for genome stability. A compelling body of evidence now suggests that researchers should be directly testing these mechanisms in models of human cancer. Twit Text FOAVip Mechanisms of genome instability induced by RNA processing defects ????Trends Genet http://www.kidney.de/pget.php?&tw=1&pmid=24794811 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24794811 #FOAvip English Wikipedia <ref>{{Cite pmid|24794811}}</ref> Mechanisms of genome instability induced by RNA processing defects #MMPMID24794811 Chan YA; Hieter P; Stirling PC Trends Genet 2014[Jun]; 30 (6): 245-53 PMID24794811show ga The role of normal transcription and RNA processing in maintaining genome integrity is becoming increasingly appreciated in organisms ranging from bacteria to humans. Several mutations in RNA biogenesis factors have been implicated in human cancers, but the mechanisms and potential connections to tumor genome instability are not clear. Here we discuss how RNA processing defects could destabilize genomes through mutagenic R-loop structures and by altering expression of genes required for genome stability. A compelling body of evidence now suggests that researchers should be directly testing these mechanisms in models of human cancer. äMechanisms of genome instability induced by RNA processing defects (epmc).pdf DeepDyve Pubget Overpricing