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10.1016/j.molcel.2014.03.025 http://scihub22266oqcxt.onion/10.1016/j.molcel.2014.03.025 C4039351!4039351 !24725595     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 243.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Warning: imagejpeg(C:\Inetpub\vhosts\kidney.de\httpdocs\phplern\24725595 .jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117       Mol+Cell 2014 ; 54 (1 ): 67-79 Nephropedia Template TP {{tp|p=24725595 |t=2014. Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function |pdf=|usr=}}{{24725595 }} gab.com Text Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function JO: Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=24725595 #FOAvip In marmoset T cells transformed by Herpesvirus saimiri (HVS), a viral U-rich noncoding (nc) RNA, HSUR 1, specifically mediates degradation of host microRNA-27 (miR-27). High-throughput sequencing of RNA after crosslinking immunoprecipitation (HITS-CLIP) identified mRNAs targeted by miR-27 as enriched in the T cell receptor (TCR) signaling pathway, including GRB2. Accordingly, transfection of miR-27 into human T cells attenuates TCR-induced activation of mitogen-activated protein kinases (MAPKs) and induction of CD69. MiR-27 also robustly regulates SEMA7A and IFN-?, key modulators and effectors of T cell function. Knockdown or ectopic expression of HSUR 1 alters levels of these proteins in virally transformed cells. Two other T-lymphotropic ?-herpesviruses, AlHV-1 and OvHV-2, do not produce a noncoding RNA to downregulate miR-27 but instead encode homologs of miR-27 target genes. Thus, oncogenic ?-herpesviruses have evolved diverse strategies to converge on common targets in host T cells. Twit Text FOAVip Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function ????Mol Cell http://www.kidney.de/pget.php?&tw=1&pmid=24725595 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24725595 #FOAvip English Wikipedia <ref>{{Cite pmid|24725595 }}</ref> Alternative capture of noncoding RNAs or protein-coding genes by herpesviruses to alter host T cell function #MMPMID24725595 Guo YE ; Riley KJ ; Iwasaki A ; Steitz JA Mol Cell 2014[Apr]; 54 (1 ): 67-79 PMID24725595 show ga In marmoset T cells transformed by Herpesvirus saimiri (HVS), a viral U-rich noncoding (nc) RNA, HSUR 1, specifically mediates degradation of host microRNA-27 (miR-27). High-throughput sequencing of RNA after crosslinking immunoprecipitation (HITS-CLIP) identified mRNAs targeted by miR-27 as enriched in the T cell receptor (TCR) signaling pathway, including GRB2. Accordingly, transfection of miR-27 into human T cells attenuates TCR-induced activation of mitogen-activated protein kinases (MAPKs) and induction of CD69. MiR-27 also robustly regulates SEMA7A and IFN-?, key modulators and effectors of T cell function. Knockdown or ectopic expression of HSUR 1 alters levels of these proteins in virally transformed cells. Two other T-lymphotropic ?-herpesviruses, AlHV-1 and OvHV-2, do not produce a noncoding RNA to downregulate miR-27 but instead encode homologs of miR-27 target genes. Thus, oncogenic ?-herpesviruses have evolved diverse strategies to converge on common targets in host T cells. |*Lymphocyte Activation [MESH] |Animals [MESH] |Antigens, CD/genetics/metabolism [MESH] |Antigens, Differentiation, T-Lymphocyte/metabolism [MESH] |Base Sequence [MESH] |Callithrix [MESH] |Enzyme Activation [MESH] |GPI-Linked Proteins/genetics/metabolism [MESH] |GRB2 Adaptor Protein/genetics/metabolism [MESH] |Gene Expression Regulation [MESH] |HEK293 Cells [MESH] |Herpesvirus 2, Saimiriine/genetics/*metabolism/pathogenicity [MESH] |High-Throughput Nucleotide Sequencing [MESH] |Host-Pathogen Interactions [MESH] |Humans [MESH] |Immunoprecipitation [MESH] |Interferon-gamma/genetics/metabolism [MESH] |Jurkat Cells [MESH] |Lectins, C-Type/metabolism [MESH] |MicroRNAs/genetics/*metabolism [MESH] |Mitogen-Activated Protein Kinases/metabolism [MESH] |Molecular Sequence Data [MESH] |RNA Stability [MESH] |RNA, Untranslated/genetics/*metabolism [MESH] |RNA, Viral/genetics/*metabolism [MESH] |Receptors, Antigen, T-Cell/genetics/metabolism [MESH] |Semaphorins/genetics/metabolism [MESH] |Sequence Analysis, RNA [MESH] |Signal Transduction [MESH] |T-Lymphocytes/immunology/*metabolism/virology [MESH] |Time Factors [MESH]Alternative capture of noncoding RNAs or protein-coding genes by herpe(epmc).pdf DeepDyve Pubget Overpricing