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10.1242/jcs.147462 http://scihub22266oqcxt.onion/10.1242/jcs.147462 C4038947!4038947!24695857     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Sci 2014 ; 127 (11): 2554-64 Nephropedia Template TP {{tp|p=24695857|t=2014. Pleiotrophin antagonizes Brd2 during neuronal differentiation |pdf=|usr=}}{{24695857}} gab.com Text Pleiotrophin antagonizes Brd2 during neuronal differentiation JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=24695857 #FOAvip Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell-cycle-associated genes and therefore involved in cell cycle progression. Brd2 is expressed in proliferating neuronal progenitors, displays cell-cycle-stimulating activity and, when overexpressed, impairs neuronal differentiation. Paradoxically, Brd2 is also detected in differentiating neurons. To shed light on the role of Brd2 in the transition from cell proliferation to differentiation, we had previously looked for proteins that interacted with Brd2 upon induction of neuronal differentiation. Surprisingly, we identified the growth factor pleiotrophin (Ptn). Here, we show that Ptn antagonized the cell-cycle-stimulating activity associated with Brd2, thus enhancing induced neuronal differentiation. Moreover, Ptn knockdown reduced neuronal differentiation. We analyzed Ptn-mediated antagonism of Brd2 in a cell differentiation model and in two embryonic processes associated with the neural tube: spinal cord neurogenesis and neural crest migration. Finally, we investigated the mechanisms of Ptn-mediated antagonism and determined that Ptn destabilizes the association of Brd2 with chromatin. Thus, Ptn-mediated Brd2 antagonism emerges as a modulation system accounting for the balance between cell proliferation and differentiation in the vertebrate nervous system. Twit Text FOAVip Pleiotrophin antagonizes Brd2 during neuronal differentiation ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=24695857 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24695857 #FOAvip English Wikipedia <ref>{{Cite pmid|24695857}}</ref> Pleiotrophin antagonizes Brd2 during neuronal differentiation #MMPMID24695857 Garcia-Gutierrez P; Juarez-Vicente F; Wolgemuth DJ; Garcia-Dominguez M J Cell Sci 2014[Jun]; 127 (11): 2554-64 PMID24695857show ga Bromodomain-containing protein 2 (Brd2) is a BET family chromatin adaptor required for expression of cell-cycle-associated genes and therefore involved in cell cycle progression. Brd2 is expressed in proliferating neuronal progenitors, displays cell-cycle-stimulating activity and, when overexpressed, impairs neuronal differentiation. Paradoxically, Brd2 is also detected in differentiating neurons. To shed light on the role of Brd2 in the transition from cell proliferation to differentiation, we had previously looked for proteins that interacted with Brd2 upon induction of neuronal differentiation. Surprisingly, we identified the growth factor pleiotrophin (Ptn). Here, we show that Ptn antagonized the cell-cycle-stimulating activity associated with Brd2, thus enhancing induced neuronal differentiation. Moreover, Ptn knockdown reduced neuronal differentiation. We analyzed Ptn-mediated antagonism of Brd2 in a cell differentiation model and in two embryonic processes associated with the neural tube: spinal cord neurogenesis and neural crest migration. Finally, we investigated the mechanisms of Ptn-mediated antagonism and determined that Ptn destabilizes the association of Brd2 with chromatin. Thus, Ptn-mediated Brd2 antagonism emerges as a modulation system accounting for the balance between cell proliferation and differentiation in the vertebrate nervous system. äPleiotrophin antagonizes Brd2 during neuronal differentiation (epmc).pdf DeepDyve Pubget Overpricing