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10.1242/jcs.144345 http://scihub22266oqcxt.onion/10.1242/jcs.144345 C4038945!4038945!24639463     free     free     free Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 211.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       J+Cell+Sci 2014 ; 127 (11): 2528-41 Nephropedia Template TP {{tp|p=24639463|t=2014. Tight coupling between nucleus and cell migration through the perinuclear actin cap |pdf=|usr=}}{{24639463}} gab.com Text Tight coupling between nucleus and cell migration through the perinuclear actin cap JO: J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=24639463 #FOAvip Although eukaryotic cells are known to alternate between ?advancing? episodes of fast and persistent movement and ?hesitation? episodes of low speed and low persistence, the molecular mechanism that controls the dynamic changes in morphology, speed and persistence of eukaryotic migratory cells remains unclear. Here, we show that the movement of the interphase nucleus during random cell migration switches intermittently between two distinct modes ? rotation and translocation ? that follow with high fidelity the sequential rounded and elongated morphologies of the nucleus and cell body, respectively. Nuclear rotation and translocation mediate the stop-and-go motion of the cell through the dynamic formation and dissolution, respectively, of the contractile perinuclear actin cap, which is dynamically coupled to the nuclear lamina and the nuclear envelope through LINC complexes. A persistent cell movement and nuclear translocation driven by the actin cap are halted following the disruption of the actin cap, which in turn allows the cell to repolarize for its next persistent move owing to nuclear rotation mediated by cytoplasmic dynein light intermediate chain 2. Twit Text FOAVip Tight coupling between nucleus and cell migration through the perinuclear actin cap ????J Cell Sci http://www.kidney.de/pget.php?&tw=1&pmid=24639463 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24639463 #FOAvip English Wikipedia <ref>{{Cite pmid|24639463}}</ref> Tight coupling between nucleus and cell migration through the perinuclear actin cap #MMPMID24639463 Kim DH; Cho S; Wirtz D J Cell Sci 2014[Jun]; 127 (11): 2528-41 PMID24639463show ga Although eukaryotic cells are known to alternate between ?advancing? episodes of fast and persistent movement and ?hesitation? episodes of low speed and low persistence, the molecular mechanism that controls the dynamic changes in morphology, speed and persistence of eukaryotic migratory cells remains unclear. Here, we show that the movement of the interphase nucleus during random cell migration switches intermittently between two distinct modes ? rotation and translocation ? that follow with high fidelity the sequential rounded and elongated morphologies of the nucleus and cell body, respectively. Nuclear rotation and translocation mediate the stop-and-go motion of the cell through the dynamic formation and dissolution, respectively, of the contractile perinuclear actin cap, which is dynamically coupled to the nuclear lamina and the nuclear envelope through LINC complexes. A persistent cell movement and nuclear translocation driven by the actin cap are halted following the disruption of the actin cap, which in turn allows the cell to repolarize for its next persistent move owing to nuclear rotation mediated by cytoplasmic dynein light intermediate chain 2. äTight coupling between nucleus and cell migration through the perinucl(epmc).pdf DeepDyve Pubget Overpricing