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10.1016/j.biocel.2014.04.003

http://scihub22266oqcxt.onion/10.1016/j.biocel.2014.04.003
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C4038153!4038153!24735711
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suck abstract from ncbi


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pmid24735711      Int+J+Biochem+Cell+Biol 2014 ; 51 (ä): 150-4
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  • Molecules in focus: C-terminal tensin-like (CTEN): a promising biomarker and target for cancer #MMPMID24735711
  • Lo SH
  • Int J Biochem Cell Biol 2014[Jun]; 51 (ä): 150-4 PMID24735711show ga
  • C-terminal tensin-like (cten, also known as tensin4, TNS4) is a member of the tensin family. Cten protein, like the other three tensin family members, localizes to focal adhesion sites but only shares sequence homology with other tensins at its C-terminal region, which contains the Src SH2 and PTB domains. Cten is abundantly expressed in normal prostate and placenta and is down-regulated in prostate cancer. However, overexpression of cten frequently associates with tumors derived from breast, colon, lung, stomach, skin and pancreas. A variety of cancer-associated growth factors and cytokines induce cten expression. Up-regulated cten promotes cell motility, prolongs epidermal growth factor receptor signaling, and enhances tumorigenicity. Emerging findings suggest that cten is a promising biomarker and therapeutic target for various cancers.
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