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10.1093/infdis/jiu009

http://scihub22266oqcxt.onion/10.1093/infdis/jiu009
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C4038140!4038140!24403559
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suck abstract from ncbi


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pmid24403559      J+Infect+Dis 2014 ; 209 (12): 2012-6
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  • Massive Mobilization of Dendritic Cells During Influenza A Virus Subtype H5N1 Infection of Nonhuman Primates #MMPMID24403559
  • Soloff AC; Bissel SJ; Junecko BF; Giles BM; Reinhart TA; Ross TM; Barratt-Boyes SM
  • J Infect Dis 2014[Jun]; 209 (12): 2012-6 PMID24403559show ga
  • Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory response, but the impact of infection on dendritic cells (DCs) is unknown. We show that influenza A virus subtype H5N1 infection rapidly and profoundly impacts DCs in cynomolgus macaques, increasing the number of blood myeloid and plasmacytoid DCs by 16- and 60-fold, respectively. Infection was associated with recruitment, activation, and apoptosis of DCs in lung-draining lymph nodes; granulocyte and macrophage infiltration in lungs was also detected, together with expression of CXCL10. This degree of DC mobilization is unprecedented in viral infection and suggests a potential role for DCs in the pathogenesis of highly pathogenic avian influenza virus.
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