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10.1093/infdis/jiu009

http://scihub22266oqcxt.onion/10.1093/infdis/jiu009
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C4038140!4038140 !24403559
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suck abstract from ncbi

pmid24403559
      J+Infect+Dis 2014 ; 209 (12 ): 2012-6
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  • Massive mobilization of dendritic cells during influenza A virus subtype H5N1 infection of nonhuman primates #MMPMID24403559
  • Soloff AC ; Bissel SJ ; Junecko BF ; Giles BM ; Reinhart TA ; Ross TM ; Barratt-Boyes SM
  • J Infect Dis 2014[Jun]; 209 (12 ): 2012-6 PMID24403559 show ga
  • Highly pathogenic avian influenza virus infection is characterized by a marked inflammatory response, but the impact of infection on dendritic cells (DCs) is unknown. We show that influenza A virus subtype H5N1 infection rapidly and profoundly impacts DCs in cynomolgus macaques, increasing the number of blood myeloid and plasmacytoid DCs by 16- and 60-fold, respectively. Infection was associated with recruitment, activation, and apoptosis of DCs in lung-draining lymph nodes; granulocyte and macrophage infiltration in lungs was also detected, together with expression of CXCL10. This degree of DC mobilization is unprecedented in viral infection and suggests a potential role for DCs in the pathogenesis of highly pathogenic avian influenza virus.
  • |*Influenza A Virus, H5N1 Subtype [MESH]
  • |Animals [MESH]
  • |Cell Proliferation [MESH]
  • |Chemokine CXCL10/genetics/metabolism [MESH]
  • |Dendritic Cells/*immunology/*virology [MESH]
  • |Lung/pathology/virology [MESH]
  • |Lymph Nodes/virology [MESH]
  • |Macaca fascicularis/virology [MESH]
  • |Macrophages/metabolism [MESH]
  • |Male [MESH]


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