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Massive mobilization of dendritic cells during influenza A virus subtype H5N1
infection of nonhuman primates
#MMPMID24403559
Soloff AC
; Bissel SJ
; Junecko BF
; Giles BM
; Reinhart TA
; Ross TM
; Barratt-Boyes SM
J Infect Dis
2014[Jun]; 209
(12
): 2012-6
PMID24403559
show ga
Highly pathogenic avian influenza virus infection is characterized by a marked
inflammatory response, but the impact of infection on dendritic cells (DCs) is
unknown. We show that influenza A virus subtype H5N1 infection rapidly and
profoundly impacts DCs in cynomolgus macaques, increasing the number of blood
myeloid and plasmacytoid DCs by 16- and 60-fold, respectively. Infection was
associated with recruitment, activation, and apoptosis of DCs in lung-draining
lymph nodes; granulocyte and macrophage infiltration in lungs was also detected,
together with expression of CXCL10. This degree of DC mobilization is
unprecedented in viral infection and suggests a potential role for DCs in the
pathogenesis of highly pathogenic avian influenza virus.