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10.1155/2014/805926 http://scihub22266oqcxt.onion/10.1155/2014/805926 C4037623!4037623!24949471     free     free     free Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 235.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Biomed+Res+Int 2014 ; 2014 (ä): ä Nephropedia Template TP {{tp|p=24949471|t=2014. Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells |pdf=|usr=}}{{24949471}} gab.com Text Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells JO: Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24949471 #FOAvip Steroid alkaloids have been suggested as potential anticancer compounds. However, the underlying mechanisms of how steroid alkaloids inhibit the tumor growth are largely unknown. Here, we reported that solanine, a substance of steroid alkaloids, has a positive effect on the inhibition of pancreatic cancer cell growth in vitro and in vivo. In pancreatic cancer cells and nu/nu nude mice model, we found that solanine inhibited cancer cells growth through caspase-3 dependent mitochondrial apoptosis. Mechanically, solanine promotes the opening of mitochondrial membrane permeability transition pore (MPTP) by downregulating the Bcl-2/Bax ratio; thereafter, Cytochrome c and Smac are released from mitochondria into cytosol to process the caspase-3 zymogen into an activated form. Moreover, we found that the expression of tumor metastasis related proteins, MMP-2 and MMP-9, was also decreased in the cells treated with solanine. Therefore, our results suggested that solanine was an effective compound for the treatment of pancreatic cancer. Twit Text FOAVip Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells ????Biomed Res Int http://www.kidney.de/pget.php?&tw=1&pmid=24949471 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24949471 #FOAvip English Wikipedia <ref>{{Cite pmid|24949471}}</ref> Solanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic Cancer Cells #MMPMID24949471 Sun H; Lv C; Yang L; Wang Y; Zhang Q; Yu S; Kong H; Wang M; Xie J; Zhang C; Zhou M Biomed Res Int 2014[]; 2014 (ä): ä PMID24949471show ga Steroid alkaloids have been suggested as potential anticancer compounds. However, the underlying mechanisms of how steroid alkaloids inhibit the tumor growth are largely unknown. Here, we reported that solanine, a substance of steroid alkaloids, has a positive effect on the inhibition of pancreatic cancer cell growth in vitro and in vivo. In pancreatic cancer cells and nu/nu nude mice model, we found that solanine inhibited cancer cells growth through caspase-3 dependent mitochondrial apoptosis. Mechanically, solanine promotes the opening of mitochondrial membrane permeability transition pore (MPTP) by downregulating the Bcl-2/Bax ratio; thereafter, Cytochrome c and Smac are released from mitochondria into cytosol to process the caspase-3 zymogen into an activated form. Moreover, we found that the expression of tumor metastasis related proteins, MMP-2 and MMP-9, was also decreased in the cells treated with solanine. Therefore, our results suggested that solanine was an effective compound for the treatment of pancreatic cancer. äSolanine Induces Mitochondria-Mediated Apoptosis in Human Pancreatic C(epmc).pdf DeepDyve Pubget Overpricing