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10.1016/j.ejphar.2013.11.013 http://scihub22266oqcxt.onion/10.1016/j.ejphar.2013.11.013 C4037395!4037395!24291103     free     free     free Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 213.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Eur+J+Pharmacol 2014 ; ä (ä): 1-3 Nephropedia Template TP {{tp|p=24291103|t=2014. Calcium signalling and calcium channels: Evolution and general principles |pdf=|usr=}}{{24291103}} gab.com Text Calcium signalling and calcium channels: Evolution and general principles JO: Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24291103 #FOAvip Calcium as a divalent ion was selected early in evolution as a signaling molecule to be used by both prokaryotes and eukaryotes. Its low cytosolic concentration likely reflects the initial concentration of this ion in the primordial soup/ocean as unicellular organisms were formed. As the concentration of calcium in the ocean subsequently increased, so did the diversity of homeostatic molecules. This includes the plasma membrane channels that allowed the calcium entry, as well as extrusion mechanisms, i.e., exchangers and pumps. Further diversification occurred with the evolution of intracellular organelles, in particular the endoplasmic reticulum and mitochondria, which also contain channels, exchanger(s) and pumps to handle the homeostasis of calcium ions. Calcium signalling system, based around coordinated interactions of the above molecular entities, can be activated by the opening of voltage-gated channels, by neurotransmitters, by second messengers and/or mechanical stimulation, and as such is all-pervading pathway in physiology and pathophysiology of organisms. Twit Text FOAVip Calcium signalling and calcium channels: Evolution and general principles ????Eur J Pharmacol http://www.kidney.de/pget.php?&tw=1&pmid=24291103 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24291103 #FOAvip English Wikipedia <ref>{{Cite pmid|24291103}}</ref> Calcium signalling and calcium channels: Evolution and general principles #MMPMID24291103 Verkhratsky A; Parpura V Eur J Pharmacol 2014[Sep]; ä (ä): 1-3 PMID24291103show ga Calcium as a divalent ion was selected early in evolution as a signaling molecule to be used by both prokaryotes and eukaryotes. Its low cytosolic concentration likely reflects the initial concentration of this ion in the primordial soup/ocean as unicellular organisms were formed. As the concentration of calcium in the ocean subsequently increased, so did the diversity of homeostatic molecules. This includes the plasma membrane channels that allowed the calcium entry, as well as extrusion mechanisms, i.e., exchangers and pumps. Further diversification occurred with the evolution of intracellular organelles, in particular the endoplasmic reticulum and mitochondria, which also contain channels, exchanger(s) and pumps to handle the homeostasis of calcium ions. Calcium signalling system, based around coordinated interactions of the above molecular entities, can be activated by the opening of voltage-gated channels, by neurotransmitters, by second messengers and/or mechanical stimulation, and as such is all-pervading pathway in physiology and pathophysiology of organisms. äCalcium signalling and calcium channels: Evolution and general princip(epmc).pdf DeepDyve Pubget Overpricing