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10.1016/j.tig.2014.03.003

http://scihub22266oqcxt.onion/10.1016/j.tig.2014.03.003
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C4037383!4037383!24780084
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suck abstract from ncbi


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pmid24780084      Trends+Genet 2014 ; 30 (6): 237-44
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  • Random Monoallelic Expression: Regulating gene expression one allele at a time #MMPMID24780084
  • Eckersley-Maslin MA; Spector DL
  • Trends Genet 2014[Jun]; 30 (6): 237-44 PMID24780084show ga
  • Monoallelic gene expression is a remarkable process in which transcription occurs from only one of two homologous alleles in a diploid cell. Interestingly, between 0.5% to 15% of autosomal genes exhibit random monoallelic gene expression, in which different cells express only one allele independently of the underlying genomic sequence, in a cell-type specific manner. Recently, genome-wide studies have increased our understanding of the cell-type specific incidence of random monoallelic gene expression, and how the imbalance in allelic expression is distinguished within the cell and potentially maintained across cell generations. Monoallelic gene expression is likely generated through stochastic independent regulation of the two alleles upon differentiation, and has varied implications for the cell and organism, in particular with respect to disease.
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