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10.1016/j.coi.2014.02.010

http://scihub22266oqcxt.onion/10.1016/j.coi.2014.02.010
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C4037377!4037377!24681449
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suck abstract from ncbi


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pmid24681449      Curr+Opin+Immunol 2014 ; ä (ä): 90-6
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  • CLONAL AND CELLULAR DYNAMICS IN GERMINAL CENTERS #MMPMID24681449
  • Victora GD; Mesin L
  • Curr Opin Immunol 2014[Jun]; ä (ä): 90-6 PMID24681449show ga
  • Germinal centers (GCs) are the site of antibody affinity maturation, a process that involves complex clonal and cellular dynamics. Selection of B cells bearing higher-affinity immunoglobulins proceeds via a stereotyped pattern where B cells migrate cyclically between the GC?s two anatomical compartments. This process occurs in a timeframe that is well suited to analysis by intravital microscopy, and much has been learned in recent years by use of these techniques. On a longer time scale, the diversity of B cell clones and variants within individual GCs is also thought to change as affinity maturation progresses; however, our understanding of clonal dynamics in individual GCs is limited. We discuss recent progress in the elucidation of clonal and cellular dynamics patterns.
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