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.jpg): Failed to open stream: No such file or directory in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 117 Acta+Diabetol
2014 ; 51
(3
): 513-6
Nephropedia Template TP
gab.com Text
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Twit Text #
English Wikipedia
Effects of erythritol on endothelial function in patients with type 2 diabetes
mellitus: a pilot study
#MMPMID24366423
Flint N
; Hamburg NM
; Holbrook M
; Dorsey PG
; LeLeiko RM
; Berger A
; de Cock P
; Bosscher D
; Vita JA
Acta Diabetol
2014[]; 51
(3
): 513-6
PMID24366423
show ga
Sugar substitutes are important in the dietary management of diabetes mellitus.
Erythritol is a non-caloric dietary bulk sweetener that reverses endothelial
dysfunction in diabetic rats. We completed a pilot study to examine the effects
of erythritol on vascular function in patients with type 2 diabetes mellitus.
Participants (n = 24) consumed erythritol 36 g/day as an orange-flavored beverage
for 4 weeks and a single dose of 24 g during the baseline and final visits. We
assessed vascular function before and after acute (2 h) and chronic (4 weeks)
erythritol consumption. Acute erythritol improved endothelial function measured
by fingertip peripheral arterial tonometry (0.52 ± 0.48 to 0.87 ± 0.29 au,
P = 0.005). Chronic erythritol decreased central pulse pressure (47 ± 13 to
41 ± 9 mmHg, P = 0.02) and tended to decrease carotid-femoral pulse wave velocity
(P = 0.06). Thus, erythritol consumption acutely improved small vessel
endothelial function, and chronic treatment reduced central aortic stiffness.
Erythritol may be a preferred sugar substitute for patients with diabetes
mellitus.
|Blood Pressure
[MESH]
|Diabetes Mellitus, Type 2/*drug therapy/physiopathology
[MESH]