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10.1002/cmdc.201300502 http://scihub22266oqcxt.onion/10.1002/cmdc.201300502 C4037345!4037345!24504646     free     free     free Deprecated: Implicit conversion from float 217.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       ChemMedChem 2014 ; 9 (6): 1131-5 Nephropedia Template TP {{tp|p=24504646|t=2014. Platinum compounds for high-resolution in vivo cancer imaging |pdf=|usr=}}{{24504646}} gab.com Text Platinum compounds for high-resolution in vivo cancer imaging JO: ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=24504646 #FOAvip Platinum(II) compounds, principally cisplatin and carboplatin, are commonly used front-line cancer therapeutics. Despite widespread use and the interest of developing new derivatives, including nanoformulations with improved properties, it has been difficult to visualize Pt compounds in live subjects, in real-time, and with subcellular resolution. Here we present four novel cisplatin- and carboplatin-derived fluorescent imaging compounds for quantitative intravital cancer imaging. We conjugate boron dipyromethene FL (BODIPY-FL) to PtII complexes for robust in vivo fluorescence, and show retained DNA-damaging and cytotoxic properties. We image pharmacokinetics and tumor uptake in a xenograft cancer mouse model. Finally, we present a genetic reporter of single-cell DNA damage for in vivo imaging, and simultaneously monitor Pt drug accumulation and resultant DNA damage in individual tumor cells, at subcellular resolution, and in real-time in a live animal model of cancer. Twit Text FOAVip Platinum compounds for high-resolution in vivo cancer imaging ????ChemMedChem http://www.kidney.de/pget.php?&tw=1&pmid=24504646 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24504646 #FOAvip English Wikipedia <ref>{{Cite pmid|24504646}}</ref> Platinum compounds for high-resolution in vivo cancer imaging #MMPMID24504646 Miller MA; Askevold B; Yang KS; Kohler R; Weissleder R ChemMedChem 2014[Jun]; 9 (6): 1131-5 PMID24504646show ga Platinum(II) compounds, principally cisplatin and carboplatin, are commonly used front-line cancer therapeutics. Despite widespread use and the interest of developing new derivatives, including nanoformulations with improved properties, it has been difficult to visualize Pt compounds in live subjects, in real-time, and with subcellular resolution. Here we present four novel cisplatin- and carboplatin-derived fluorescent imaging compounds for quantitative intravital cancer imaging. We conjugate boron dipyromethene FL (BODIPY-FL) to PtII complexes for robust in vivo fluorescence, and show retained DNA-damaging and cytotoxic properties. We image pharmacokinetics and tumor uptake in a xenograft cancer mouse model. Finally, we present a genetic reporter of single-cell DNA damage for in vivo imaging, and simultaneously monitor Pt drug accumulation and resultant DNA damage in individual tumor cells, at subcellular resolution, and in real-time in a live animal model of cancer. äPlatinum compounds for high-resolution in vivo cancer imaging (epmc).pdf DeepDyve Pubget Overpricing