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10.14336/AD.2014.0500203 http://scihub22266oqcxt.onion/10.14336/AD.2014.0500203 C4037312!4037312!24900943     free     free     free Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 209.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Aging+Dis 2014 ; 5 (3): 203-11 Nephropedia Template TP {{tp|p=24900943|t=2014. Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases |pdf=|usr=}}{{24900943}} gab.com Text Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases JO: Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=24900943 #FOAvip Accumulating evidence has revealed that thePI3K/AKT/PTENpathway acts as a pivotal determinant of cell fate regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. NADPH oxidase (NOX) family of enzymes generates the ROS. The regulation of NOX enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. Cells are continuously exposed to the ROS, which represent mutagens and are thought to be a major contributor to several diseases including cancer and aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, the roles of oxidative stress in PI3K/AKT/PTEN signaling are summarized with a focus on the links between the pathways and NOX protein in several diseases including cancer and aging. Twit Text FOAVip Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases ????Aging Dis http://www.kidney.de/pget.php?&tw=1&pmid=24900943 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24900943 #FOAvip English Wikipedia <ref>{{Cite pmid|24900943}}</ref> Link between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases #MMPMID24900943 Nakanishi A; Wada Y; Kitagishi Y; Matsuda S Aging Dis 2014[Jun]; 5 (3): 203-11 PMID24900943show ga Accumulating evidence has revealed that thePI3K/AKT/PTENpathway acts as a pivotal determinant of cell fate regarding senescence and apoptosis, which is mediated by intracellular reactive oxygen species (ROS) generation. NADPH oxidase (NOX) family of enzymes generates the ROS. The regulation of NOX enzymes is complex, with many members of this family exhibiting complexity in terms of subunit composition, cellular location, and tissue-specific expression. Cells are continuously exposed to the ROS, which represent mutagens and are thought to be a major contributor to several diseases including cancer and aging process. Therefore, cellular ROS sensing and metabolism are firmly regulated by a variety of proteins involved in the redox mechanism. In this review, the roles of oxidative stress in PI3K/AKT/PTEN signaling are summarized with a focus on the links between the pathways and NOX protein in several diseases including cancer and aging. äLink between PI3K/AKT/PTEN Pathway and NOX Proteinin Diseases (epmc).pdf DeepDyve Pubget Overpricing