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10.1093/aje/kwu067 http://scihub22266oqcxt.onion/10.1093/aje/kwu067 C4036218!4036218!24771724     free     free     free Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 231.6 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534 Deprecated: Implicit conversion from float 265.2 to int loses precision in C:\Inetpub\vhosts\kidney.de\httpdocs\pget.php on line 534       Am+J+Epidemiol 2014 ; 179 (11): 1331-9 Nephropedia Template TP {{tp|p=24771724|t=2014. Fibrosis-Related Biomarkers and Risk of Total and Cause-Specific Mortality: The Cardiovascular Health Study |pdf=|usr=}}{{24771724}} gab.com Text Fibrosis-Related Biomarkers and Risk of Total and Cause-Specific Mortality: The Cardiovascular Health Study JO: Am J Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=24771724 #FOAvip Fibrosis has been implicated in diverse diseases of the liver, kidney, lungs, and heart, but its importance as a risk factor for mortality remains unconfirmed. We determined the prospective associations of 2 complementary biomarkers of fibrosis, transforming growth factor-? (TGF-?) and procollagen type III N-terminal propeptide (PIIINP), with total and cause-specific mortality risks among community-living older adults in the Cardiovascular Health Study (1996?2010). We measured circulating TGF-? and PIIINP levels in plasma samples collected in 1996 and ascertained the number of deaths through 2010. Both TGF-? and PIIINP were associated with elevated risks of total and pulmonary mortality after adjustment for sociodemographic, clinical, and biochemical risk factors. For total mortality, the hazard ratios per doubling of TGF-? and PIIINP were 1.09 (95% confidence interval (CI): 1.01, 1.17; P = 0.02) and 1.14 (CI: 1.03, 1.27; P = 0.01), respectively. The corresponding hazard ratios for pulmonary mortality were 1.27 (CI: 1.01, 1.60; P = 0.04) for TGF-? and 1.52 (CI: 1.11, 2.10; P = 0.01) for PIIINP. Associations of TGF-? and PIIINP with total and pulmonary mortality were strongest among individuals with higher C-reactive protein concentrations (P for interaction < 0.05). Our findings provide some of the first large-scale prospective evidence that circulating biomarkers of fibrosis measured late in life are associated with death. Twit Text FOAVip Fibrosis-Related Biomarkers and Risk of Total and Cause-Specific Mortality: The Cardiovascular Health Study ????Am J Epidemiol http://www.kidney.de/pget.php?&tw=1&pmid=24771724 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24771724 #FOAvip English Wikipedia <ref>{{Cite pmid|24771724}}</ref> Fibrosis-Related Biomarkers and Risk of Total and Cause-Specific Mortality: The Cardiovascular Health Study #MMPMID24771724 Agarwal I; Glazer NL; Barasch E; Biggs ML; Djoussé L; Fitzpatrick AL; Gottdiener JS; Ix JH; Kizer JR; Rimm EB; Siscovick DS; Tracy RP; Zieman SJ; Mukamal KJ Am J Epidemiol 2014[Jun]; 179 (11): 1331-9 PMID24771724show ga Fibrosis has been implicated in diverse diseases of the liver, kidney, lungs, and heart, but its importance as a risk factor for mortality remains unconfirmed. We determined the prospective associations of 2 complementary biomarkers of fibrosis, transforming growth factor-? (TGF-?) and procollagen type III N-terminal propeptide (PIIINP), with total and cause-specific mortality risks among community-living older adults in the Cardiovascular Health Study (1996?2010). We measured circulating TGF-? and PIIINP levels in plasma samples collected in 1996 and ascertained the number of deaths through 2010. Both TGF-? and PIIINP were associated with elevated risks of total and pulmonary mortality after adjustment for sociodemographic, clinical, and biochemical risk factors. For total mortality, the hazard ratios per doubling of TGF-? and PIIINP were 1.09 (95% confidence interval (CI): 1.01, 1.17; P = 0.02) and 1.14 (CI: 1.03, 1.27; P = 0.01), respectively. The corresponding hazard ratios for pulmonary mortality were 1.27 (CI: 1.01, 1.60; P = 0.04) for TGF-? and 1.52 (CI: 1.11, 2.10; P = 0.01) for PIIINP. Associations of TGF-? and PIIINP with total and pulmonary mortality were strongest among individuals with higher C-reactive protein concentrations (P for interaction < 0.05). Our findings provide some of the first large-scale prospective evidence that circulating biomarkers of fibrosis measured late in life are associated with death. äFibrosis-Related Biomarkers and Risk of Total and Cause-Specific Morta(epmc).pdf DeepDyve Pubget Overpricing