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10.1016/j.gde.2013.11.018 http://scihub22266oqcxt.onion/10.1016/j.gde.2013.11.018 C4035456!4035456!24480294     free     free     free       Curr+Opin+Genet+Dev 2014 ; ä (ä): 43-9 Nephropedia Template TP {{tp|p=24480294|t=2014. Nuclear pore interactions with the genome |pdf=|usr=}}{{24480294}} gab.com Text Nuclear pore interactions with the genome JO: Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=24480294 #FOAvip Within the nucleus, chromatin is functionally organized into distinct nuclear compartments. The nuclear periphery, containing Nuclear Pore Complexes (NPCs), plays an important role in the spatial organization of chromatin and in transcriptional regulation. The role of Nuclear Pore Proteins (Nups) in transcription and their involvement in leukemia and viral integration has renewed interest in understanding their mechanism of action. Nups bind to both repressed and active genes, often in a regulated fashion. Nups can associate with chromatin both at the NPC and inside the nucleoplasm. These interactions are guided by evolutionarily conserved mechanisms that involve promoter DNA elements and trans-acting factors. These interactions can also lead to interchromosomal clustering of co-regulated genes. Nups affect gene expression by promoting stronger transcription, by limiting the spread of repressed chromatin or by altering chromatin structure. Nups can epigenetic regulation by establishing boundary elements and poising recently repressed genes for faster reactivation. Twit Text FOAVip Nuclear pore interactions with the genome ????Curr Opin Genet Dev http://www.kidney.de/pget.php?&tw=1&pmid=24480294 #FOAvip Twit Text # Free Paper on # # # # # LINK http://www.kidney.de/pget.php?&tw=1&pmid=24480294 #FOAvip English Wikipedia <ref>{{Cite pmid|24480294}}</ref> Nuclear pore interactions with the genome #MMPMID24480294 Sood V; Brickner JH Curr Opin Genet Dev 2014[Apr]; ä (ä): 43-9 PMID24480294show ga Within the nucleus, chromatin is functionally organized into distinct nuclear compartments. The nuclear periphery, containing Nuclear Pore Complexes (NPCs), plays an important role in the spatial organization of chromatin and in transcriptional regulation. The role of Nuclear Pore Proteins (Nups) in transcription and their involvement in leukemia and viral integration has renewed interest in understanding their mechanism of action. Nups bind to both repressed and active genes, often in a regulated fashion. Nups can associate with chromatin both at the NPC and inside the nucleoplasm. These interactions are guided by evolutionarily conserved mechanisms that involve promoter DNA elements and trans-acting factors. These interactions can also lead to interchromosomal clustering of co-regulated genes. Nups affect gene expression by promoting stronger transcription, by limiting the spread of repressed chromatin or by altering chromatin structure. Nups can epigenetic regulation by establishing boundary elements and poising recently repressed genes for faster reactivation. äNuclear pore interactions with the genome (epmc).pdf DeepDyve Pubget Overpricing